Ythdf1 YTH N6-methyladenosine RNA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ythdf1provided by MGI
Official Full Name: YTH N6-methyladenosine RNA binding protein 1provided by MGI
Primary source: MGI:MGI:1917431
See related: Ensembl:ENSMUSG00000038848 AllianceGenome:MGI:1917431
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8030473O16; 2210410K23Rik
Summary: Enables N6-methyladenosine-containing RNA reader activity. Involved in several processes, including learning or memory; post-transcriptional regulation of gene expression; and regulation of long-term synaptic potentiation. Located in cytoplasm. Is expressed in brain; future spinal cord; intestine; liver; and spinal cord. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human YTHDF1 (YTH N6-methyladenosine RNA binding protein F1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 20.8), CNS E11.5 (RPKM 17.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180546170..180562729, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180904377..180920936, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury.
Title: Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury.
YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice.
Title: YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice.
Mettl3-m6A-YTHDF1 axis promotion of mitochondrial dysfunction in metabolic dysfunction-associated steatotic liver disease.
Title: Mettl3-m6A-YTHDF1 axis promotion of mitochondrial dysfunction in metabolic dysfunction-associated steatotic liver disease.
YTHDF1 is pivotal for maintenance of cardiac homeostasis.
Title: YTHDF1 is pivotal for maintenance of cardiac homeostasis.
Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated Cdc25A Translation.
Title: Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated Cdc25A Translation.
m[6]A modification associated with YTHDF1 is involved in Japanese encephalitis virus infection.
Title: m(6)A modification associated with YTHDF1 is involved in Japanese encephalitis virus infection.
YTHDF1 mitigates acute kidney injury via safeguarding m[6]A-methylated mRNAs in stress granules of renal tubules.
Title: YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules.
The m[6]A reader YTHDF1 attenuates fulminant hepatitis via MFG-E8 translation in an m[6]A dependent manner.
Title: The m(6)A reader YTHDF1 attenuates fulminant hepatitis via MFG-E8 translation in an m(6)A dependent manner.
Targeting m[6]A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer.
Title: Targeting m(6)A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer.
METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome.
Title: METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9) 1 citation
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	IBA Inferred from Biological aspect of Ancestor more info
enables N6-methyladenosine-containing RNA reader activity	IDA Inferred from Direct Assay more info	PubMed
enables N6-methyladenosine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA destabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in organelle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in positive regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: YTH domain-containing family protein 1

Names: DACA-1 homolog; YTH domain family 1; YTH domain family protein 1; dermatomyositis associated with cancer putative autoantigen 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.