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    GIT2 GIT ArfGAP 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 708092, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GIT2provided by VGNC
    Official Full Name
    GIT ArfGAP 2provided by VGNC
    Primary source
    VGNC:VGNC:73054
    See related
    Ensembl:ENSMMUG00000010484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See GIT2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (109581508..109648042, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (109865333..109931794, complement)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene glycolipid transfer protein Neighboring gene trichoplein keratin filament binding Neighboring gene ankyrin repeat domain 13A Neighboring gene uncharacterized LOC114670946 Neighboring gene chromosome 11 C12orf76 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ARF GTPase-activating protein GIT2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266994.1 → NP_001253923.1  ARF GTPase-activating protein GIT2

      See identical proteins and their annotated locations for NP_001253923.1

      Status: PROVISIONAL

      Source sequence(s)
      JV044205
      UniProtKB/TrEMBL
      G7N5F9, I0FIK0
      Related
      ENSMMUP00000038661.3, ENSMMUT00000045622.3
      Conserved Domains (7) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:638 → 752
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      109581508..109648042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015152743.2 → XP_015008229.2  ARF GTPase-activating protein GIT2 isoform X9

      UniProtKB/TrEMBL
      G7N5F9
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:265 → 292
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:587 → 701
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    2. XM_015152737.2 → XP_015008223.2  ARF GTPase-activating protein GIT2 isoform X3

      UniProtKB/TrEMBL
      G7N5F9
      Related
      ENSMMUP00000013752.4, ENSMMUT00000014680.4
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:265 → 292
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:637 → 751
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:413 → 477
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    3. XM_015152736.2 → XP_015008222.2  ARF GTPase-activating protein GIT2 isoform X2

      UniProtKB/TrEMBL
      G7N5F9
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:267 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:639 → 753
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:415 → 479
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    4. XM_015152752.2 → XP_015008238.2  ARF GTPase-activating protein GIT2 isoform X16

      UniProtKB/TrEMBL
      A0A5F7ZA17
      Related
      ENSMMUP00000013753.4, ENSMMUT00000014681.4
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:480 → 591
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_015152742.2 → XP_015008228.2  ARF GTPase-activating protein GIT2 isoform X8

      UniProtKB/TrEMBL
      G7N5F9
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:268 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:590 → 704
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    6. XM_015152741.2 → XP_015008227.2  ARF GTPase-activating protein GIT2 isoform X7

      UniProtKB/TrEMBL
      I0FIK1
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:268 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:595 → 709
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:416 → 465
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    7. XM_015152738.2 → XP_015008224.2  ARF GTPase-activating protein GIT2 isoform X4

      UniProtKB/TrEMBL
      G7N5F9
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:268 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:625 → 739
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:416 → 465
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    8. XM_015152751.2 → XP_015008237.2  ARF GTPase-activating protein GIT2 isoform X15

      UniProtKB/TrEMBL
      A0A5F7ZA17
      Related
      ENSMMUP00000062437.1, ENSMMUT00000099676.1
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:268 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:527 → 641
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:416 → 476
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    9. XM_015152748.2 → XP_015008234.2  ARF GTPase-activating protein GIT2 isoform X13

      UniProtKB/TrEMBL
      A0A5F7ZA17
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:555 → 671
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:416 → 467
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    10. XM_015152739.2 → XP_015008225.2  ARF GTPase-activating protein GIT2 isoform X5

      UniProtKB/TrEMBL
      I0FIK1
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:268 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:610 → 724
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:416 → 480
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    11. XM_015152735.2 → XP_015008221.2  ARF GTPase-activating protein GIT2 isoform X1

      UniProtKB/TrEMBL
      G7N5F9
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:268 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:640 → 754
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:416 → 480
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    12. XM_015152744.2 → XP_015008230.2  ARF GTPase-activating protein GIT2 isoform X10

      UniProtKB/TrEMBL
      A0A5F7ZJ47
      Conserved Domains (6) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:206 → 233
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:578 → 692
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:354 → 418
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

    13. XM_015152745.2 → XP_015008231.2  ARF GTPase-activating protein GIT2 isoform X10

      UniProtKB/TrEMBL
      A0A5F7ZJ47
      Related
      ENSMMUP00000065201.1, ENSMMUT00000086472.1
      Conserved Domains (6) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:206 → 233
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:578 → 692
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:354 → 418
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

    14. XM_015152747.2 → XP_015008233.2  ARF GTPase-activating protein GIT2 isoform X12

      UniProtKB/TrEMBL
      H9YWJ1, I0FIK1
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:266 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:558 → 672
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    15. XM_015152740.2 → XP_015008226.2  ARF GTPase-activating protein GIT2 isoform X6

      UniProtKB/TrEMBL
      H9EU99, I0FIK1
      Related
      ENSMMUP00000081123.1, ENSMMUT00000084215.1
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:266 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:608 → 722
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:414 → 478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    16. XM_015152749.2 → XP_015008235.2  ARF GTPase-activating protein GIT2 isoform X14

      UniProtKB/TrEMBL
      I0FIK1
      Conserved Domains (6) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:204 → 231
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:546 → 660
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:352 → 416
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

    17. XM_015152746.2 → XP_015008232.2  ARF GTPase-activating protein GIT2 isoform X11

      UniProtKB/TrEMBL
      I0FIK1
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:268 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:560 → 674
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf

    18. XM_015152753.2 → XP_015008239.1  ARF GTPase-activating protein GIT2 isoform X17

      UniProtKB/TrEMBL
      F7BFP0, F7BFR5
      Related
      ENSMMUP00000013751.4, ENSMMUT00000014679.4
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 465
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
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