scrib scribble [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: scribprovided by FlyBase
Official Full Name: scribbleprovided by FlyBase
Primary source: FLYBASE:FBgn0263289
Locus tag: Dmel_CG43398
See related: AllianceGenome:FB:FBgn0263289
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0424/05; CG31082; CG42614; CG43398; CG5462; CG5467; CT17324; Dmel\CG43398; ird; ird15; l(3)673; l(3)c00119; l(3)j7B3; l(3)S042405; Lap4; MENE (3R)-F; Scb; SCR; scrb; Scrb; Scrib; SCRIB; Scribble; smi97B; vart
Old locus tag: Dmel_CG31082; Dmel_CG42614; Dmel_CG5462; Dmel_CG5467
Summary: Predicted to enable protein kinase binding activity. Involved in several processes, including apical junction assembly; basal protein localization; and morphogenesis of an epithelium. Located in several cellular components, including apicolateral plasma membrane; basolateral part of cell; and basolateral plasma membrane. Is active in apical cortex. Is expressed in several structures, including gut section; organism subdivision; presumptive embryonic/larval system; somatic stem cell; and synaptic neuropil domain. Used to study benign neoplasm; cancer; carcinoma; and kidney cancer. Orthologous to several human genes including SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 97B9-97C2; 3-91 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26536350..26604051)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (22362072..22429773)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
Title: The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
Distinct activities of Scrib module proteins organize epithelial polarity.
Title: Distinct activities of Scrib module proteins organize epithelial polarity.
such Egr-induced necrosis depends on the catalytic activity of the initiator caspase Dronc and the input from JNK signaling but is independent of their roles in apoptosis. Further mosaic analysis with mutants of scribble (scrib), suggests that Egr/JNK-mediated apoptosis and necrosis establish a two-layered defense system to inhibit the oncogenic growth of scrib mutant cells
Title: Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression.
An Activating Mutation in ERK Causes Hyperplastic Tumors in a scribble Mutant Tissue in Drosophila.
Title: An Activating Mutation in ERK Causes Hyperplastic Tumors in a scribble Mutant Tissue in Drosophila.
the Scribble/Dlg module plays multiple roles in polarity initiation
Title: Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity.
Scrib and Dlg are key components of the tricellular junction.
Title: Scribble and Discs Large mediate tricellular junction formation.
Here we show that the crucial role for Scrib in apicobasal polarity has remained obscure due to the compensatory function of two other LAP proteins, Erbin and Lano.
Title: Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex.
dynamic MAPK signaling activity, fueled by intratumor heterogeneity derived from tissue topological differences, drives a growth arrest-to-proliferation transition in scrib mutant tumors.
Title: Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors.
Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation.
Title: Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation.
The reduced expression of Parkin and HtrA2 interpret defective mitophagy leading to clustering of fragmented mitochondria and apoptotic inhibition in scrib knockdown tumors.
Title: scribble (scrib) knockdown induces tumorigenesis by modulating Drp1-Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 26558383-26565637 mobile_element_type = transposon:Stalker{}1427

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R3/R4 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior axis specification, follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basal protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment involved in pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in establishment of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of polarity of embryonic epithelium	TAS Traceable Author Statement more info	PubMed
involved_in establishment or maintenance of polarity of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of polarity of larval imaginal disc epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of a polarized epithelium	TAS Traceable Author Statement more info	PubMed
involved_in morphogenesis of embryonic epithelium	TAS Traceable Author Statement more info	PubMed
involved_in morphogenesis of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of larval imaginal disc epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zonula adherens assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed
located_in septate junction	NAS Non-traceable Author Statement more info	PubMed
located_in septate junction	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: scribble

Names: CG43398-PA; CG43398-PB; CG43398-PC; CG43398-PD; CG43398-PH; CG43398-PI; CG43398-PJ; CG43398-PK; CG43398-PL; CG43398-PM; CG43398-PN; CG43398-PO; CG43398-PP; CG43398-PQ; CG43398-PR; CG43398-PS; CG43398-PT; CG43398-PU; gp150-like; immune response deficient 15; lethal (3) c00119; scrib-PA; scrib-PB; scrib-PC; scrib-PD; scrib-PH; scrib-PI; scrib-PJ; scrib-PK; scrib-PL; scrib-PM; scrib-PN; scrib-PO; scrib-PP; scrib-PQ; scrib-PR; scrib-PS; scrib-PT; scrib-PU; scribbled; scribbles; smell impaired 97B; vartul

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

26536350..26604051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260392.1 → NP_001247321.1 scribble, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247321.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7W1

Conserved Domains (6) summary

smart00228
Location:753 → 841

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1266 → 1355

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001170275.2 → NP_001163746.1 scribble, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163746.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIZ0

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1336 → 1425

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001170276.3 → NP_001163747.1 scribble, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163747.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIZ2

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1241 → 1330

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001260389.1 → NP_001247318.1 scribble, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247318.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KRY7

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1241 → 1330

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001260391.1 → NP_001247320.1 scribble, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247320.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6M4

Conserved Domains (6) summary

smart00228
Location:753 → 841

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1266 → 1355

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001170274.2 → NP_001163745.1 scribble, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163745.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIZ1

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1336 → 1425

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001260393.1 → NP_001247322.1 scribble, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247322.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K784

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1241 → 1330

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_080015.4 → NP_524754.2 scribble, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524754.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4K7L2, A4V3G5, Q59DT7, Q59DT8, Q6AWK8, Q7K9X1, Q7KA36, Q7KRY7, Q86QS7, Q86QS8, Q86QS9, Q86QT0, Q8IMR8, Q8IMR9, Q8T003, Q95SV4, Q9VBE4

Related

FBpp0300849

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1336 → 1425

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001276060.1 → NP_001262989.1 scribble, isoform U [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262989.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHY2

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1251 → 1340

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001043296.3 → NP_001036761.3 scribble, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036761.3

Status: REVIEWED

UniProtKB/TrEMBL

U3RC96

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1241 → 1330

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_170275.3 → NP_733154.1 scribble, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733154.1

Status: REVIEWED

UniProtKB/TrEMBL

U3RC96

Related

FBpp0300844

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1241 → 1330

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001014670.4 → NP_001014670.2 scribble, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014670.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KRY7

Conserved Domains (6) summary

smart00228
Location:817 → 905

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1424 → 1513

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001276059.1 → NP_001262988.1 scribble, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262988.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KI37

Conserved Domains (8) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1251 → 1340

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam08648
Location:1708 → 1795

DUF1777; Protein of unknown function (DUF1777)

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam12871
Location:1697 → 1772

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001260390.2 → NP_001247319.1 scribble, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247319.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6I1

Conserved Domains (8) summary

smart00228
Location:753 → 841

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1361 → 1450

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam08648
Location:1818 → 1905

DUF1777; Protein of unknown function (DUF1777)

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam12871
Location:1807 → 1882

PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_170276.3 → NP_733155.2 scribble, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733155.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KRY7

Conserved Domains (6) summary

smart00228
Location:753 → 841

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1361 → 1450

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001014669.3 → NP_001014669.1 scribble, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014669.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KRY7

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1336 → 1425

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_170277.4 → NP_733156.1 scribble, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733156.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KRY7

Related

FBpp0300848

Conserved Domains (6) summary

smart00228
Location:728 → 816

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00116
Location:13 → 283

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:931 → 1016

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:39 → 61

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:337 → 375

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:198 → 256

LRR_8; Leucine rich repeat
NM_001276058.1 → NP_001262987.1 scribble, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262987.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHN3

Conserved Domains (2) summary

smart00228
Location:97 → 185

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:610 → 699

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4K6I1		A0A0B4K6I1
A0A0B4K6M4		A0A0B4K6M4
A0A0B4K784		A0A0B4K784
A0A0B4K7W1		A0A0B4K7W1
A0A0B4KHN3		A0A0B4KHN3
A0A0B4KHY2		A0A0B4KHY2
A0A0B4KI37		A0A0B4KI37
E1JIZ0		E1JIZ0
E1JIZ1		E1JIZ1
E1JIZ2		E1JIZ2
Q7KRY7.1		Q7KRY7
Q95SR1		Q95SR1