loco locomotion defects [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: locoprovided by FlyBase
Official Full Name: locomotion defectsprovided by FlyBase
Primary source: FLYBASE:FBgn0020278
Locus tag: Dmel_CG5248
See related: AllianceGenome:FB:FBgn0020278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17229; CG5248; dLoco; Dmel\CG5248; Loco; LOCO
Summary: Enables G-protein alpha-subunit binding activity; GDP-dissociation inhibitor activity; and GTPase activator activity. Involved in several processes, including nervous system development; oogenesis; and septate junction assembly. Located in apical cortex and plasma membrane. Is expressed in several structures, including epithelium; female germline cell; glial cell; head epidermis primordium; and sensory nervous system primordium. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94B6-94B8; 3-75 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22619968..22639387, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18445690..18465109, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effects of the interaction of Rpd3 and Loco on longevity in D. melanogaster are reported.
Title: Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA.
RGS proteins, such as Loco, with with GTPase-activating protein (GAP) activity affect both stress resistance and longevity in several species.
Title: Regulation of longevity by regulator of G-protein signaling protein, Loco.
Rap/Fzr targets Loco for ubiquitination, thereby regulating glial differentiation in the developing nervous system.
Title: Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein.
specific isoforms of loco are required for the differentiation of the male gonad and genital disc
Title: The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster.
Loco was identified and a functional analysis made.
Title: Identification and functional analysis of the Drosophila gene loco.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon ensheathment in central nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification, ovarian follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of glial blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of asymmetric cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: locomotion defects

Names: CG5248-PB; CG5248-PC; CG5248-PD; CG5248-PF; CG5248-PH; loco-PB; loco-PC; loco-PD; loco-PF; loco-PH; locomotion defect

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

22619968..22639387 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170030.2 → NP_732773.1 locomotion defects, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732773.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NGQ0, Q9UB06, Q9VCX1, Q9XYX8

Related

FBpp0083666

Conserved Domains (5) summary

smart00455
Location:1144 → 1213

RBD; Raf-like Ras-binding domain

cd01817
Location:1073 → 1145

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08706
Location:828 → 941

RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins

cd00992
Location:69 → 145

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:251 → 391

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
NM_170032.3 → NP_732775.1 locomotion defects, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732775.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VCX2

Related

FBpp0083668

Conserved Domains (3) summary

smart00455
Location:778 → 847

RBD; Raf-like Ras-binding domain

cd01817
Location:707 → 779

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08706
Location:462 → 575

RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
NM_001260312.2 → NP_001247241.1 locomotion defects, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247241.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7N2

Conserved Domains (3) summary

smart00455
Location:385 → 454

RBD; Raf-like Ras-binding domain

cd01817
Location:314 → 386

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08706
Location:69 → 182

RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
NM_170033.3 → NP_732776.1 locomotion defects, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732776.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IN00

Related

FBpp0083669

Conserved Domains (3) summary

smart00455
Location:432 → 501

RBD; Raf-like Ras-binding domain

cd01817
Location:361 → 433

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08706
Location:116 → 229

RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
NM_001260311.1 → NP_001247240.1 locomotion defects, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247240.1

Status: REVIEWED

UniProtKB/TrEMBL

D5A7N8

Conserved Domains (3) summary

smart00455
Location:449 → 518

RBD; Raf-like Ras-binding domain

cd01817
Location:378 → 450

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08706
Location:133 → 246

RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins