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    Rtnl2 Rtnl2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rtnl2provided by FlyBase
    Official Full Name
    Rtnl2provided by FlyBase
    Primary source
    FLYBASE:FBgn0015831
    Locus tag
    Dmel_CG1279
    See related
    AllianceGenome:FB:FBgn0015831
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.134; CG1279; Dmel\CG1279; rtnl2; Tml84D; trop
    Summary
    Enables phospholipid binding activity. Involved in endoplasmic reticulum tubular network organization and membrane bending. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rtnl2 in Genome Data Viewer
    Location:
    84D9-84D9; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7528864..7530241, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3354586..3355963, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Esterase-7 Neighboring gene alpha-Esterase-6 Neighboring gene pseudo Neighboring gene alpha-Tubulin at 84D Neighboring gene alpha-Esterase-5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon. Espadas J, et al. Nat Commun, 2019 Nov 22. PMID 31757972, Free PMC Article
    2. Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics. Pérez-Moreno JJ, et al. J Cell Biol, 2023 Jun 5. PMID 36952540, Free PMC Article
    3. Development of dendrite polarity in Drosophila neurons. Hill SE, et al. Neural Dev, 2012 Oct 30. PMID 23111238, Free PMC Article
    4. Molecular cloning of an alpha-esterase gene cluster on chromosome 3r of Drosophila melanogaster. Russell RJ, et al. Insect Biochem Mol Biol, 1996 Mar. PMID 8900595
    5. Kinesin-2 and Apc function at dendrite branch points to resolve microtubule collisions. Weiner AT, et al. Cytoskeleton (Hoboken), 2016 Jan. PMID 26785384, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane bending IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rtnl2
    Names
    CG1279-PB
    CG1279-PC
    Reticulon-2
    Rtnl2-PB
    Rtnl2-PC
    Tropomyosin-like-84D
    tropomyosin-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7528864..7530241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260035.1 → NP_001246964.1  Rtnl2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL7, Q9VIB7
      Conserved Domains (1) summary
      pfam02453
      Location:21 → 183
      Reticulon; Reticulon

    2. NM_079539.2 → NP_524263.2  Rtnl2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524263.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL7, Q9VIB7
      Conserved Domains (1) summary
      pfam02453
      Location:21 → 183
      Reticulon; Reticulon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24199 Q24199
    Q9VIB7 Q9VIB7

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