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    vanin-like vanin-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vanin-likeprovided by FlyBase
    Official Full Name
    vanin-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040069
    Locus tag
    Dmel_CG32754
    See related
    AllianceGenome:FB:FBgn0040069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32754; CG3648; Dmel\CG32754; Vanin-like
    Summary
    Predicted to enable pantetheine hydrolase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vanin-like in Genome Data Viewer
    Location:
    5E1-5E1; 1-16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6200188..6202559, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6094221..6096592, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Biotinidase Neighboring gene ER GDP-fucose transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ESTs description of the new Vanin gene family conserved from fly to human. Granjeaud S, et al. Immunogenetics, 1999 Oct. PMID 10501839
    2. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
    3. Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila. Logan-Garbisch T, et al. G3 (Bethesda), 2014 Nov 11. PMID 25387828, Free PMC Article
    4. The Impact of Microbiome and Microbiota-Derived Sodium Butyrate on Drosophila Transcriptome and Metabolome Revealed by Multi-Omics Analysis. Zhou F, et al. Metabolites, 2021 May 6. PMID 34066348, Free PMC Article
    5. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantetheine hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extrinsic component of membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vanin-like
    Names
    CG32754-PA
    pantetheine hydrolase
    vanin-like-PA
    NP_572297.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6200188..6202559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132069.3 → NP_572297.1  vanin-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NFP1, Q9W431
      Related
      FBpp0070844
      Conserved Domains (1) summary
      cd07567
      Location:33 → 304
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NFP1.1 Q9NFP1

    Gene LinkOut

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