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    P2rx2 purinergic receptor P2X 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114115, updated on 3-Dec-2024

    Summary

    Official Symbol
    P2rx2provided by RGD
    Official Full Name
    purinergic receptor P2X 2provided by RGD
    Primary source
    RGD:620251
    See related
    EnsemblRapid:ENSRNOG00000037456 AllianceGenome:RGD:620251
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P2X2
    Summary
    Enables several functions, including anion binding activity; extracellularly ATP-gated monoatomic cation channel activity; and transition metal ion binding activity. Involved in several processes, including neuronal action potential; regulation of presynaptic cytosolic calcium ion concentration; and response to ischemia. Located in several cellular components, including dendritic spine; neuronal cell body; and presynaptic membrane. Part of receptor complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 23.9), Uterus (RPKM 10.3) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See P2rx2 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (51999107..52002627)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (46338979..46342891)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (52397666..52401005)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481339 Neighboring gene fibrosin-like 1 Neighboring gene leucine rich colipase-like 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene DNA polymerase epsilon, catalytic subunit Neighboring gene peroxisomal membrane protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cobalt ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables extracellularly ATP-gated monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables extracellularly ATP-gated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables extracellularly ATP-gated monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellularly ATP-gated monoatomic cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables extracellularly ATP-gated monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mercury ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nickel cation binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables purinergic nucleotide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables suramin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of hypoxic conditions in blood by carotid body chemoreceptor signaling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within detection of hypoxic conditions in blood by carotid body chemoreceptor signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuromuscular synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuromuscular synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuronal action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peristalsis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within peristalsis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic cytosolic calcium ion concentration EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to carbohydrate IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to carbohydrate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sensory perception of taste ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urinary bladder smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within urinary bladder smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal dense core vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    P2X purinoceptor 2
    Names
    ATP receptor
    purinergic receptor P2X, ligand-gated ion channel, 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053656.3NP_446108.2  P2X purinoceptor 2

      See identical proteins and their annotated locations for NP_446108.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      O54868, P49653
      UniProtKB/TrEMBL
      Q78DW3
      Conserved Domains (1) summary
      TIGR00863
      Location:1367
      P2X; cation transporter protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      51999107..52002627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598234.3XP_017453723.1  P2X purinoceptor 2 isoform X2

      UniProtKB/TrEMBL
      A0A140TAH4, A6J2A7
    2. XM_017598236.3XP_017453725.1  P2X purinoceptor 2 isoform X6

      UniProtKB/TrEMBL
      Q78DW4
    3. XM_063270983.1XP_063127053.1  P2X purinoceptor 2 isoform X9

      UniProtKB/TrEMBL
      A0A140TAH4, A6J2A7
    4. XM_008769305.4XP_008767527.1  P2X purinoceptor 2 isoform X3

      See identical proteins and their annotated locations for XP_008767527.1

      UniProtKB/TrEMBL
      A0A140TAH4, A6J2A7, A6J2B0
      Related
      ENSRNOP00000053532.2, ENSRNOT00000056693.5
      Conserved Domains (1) summary
      TIGR00863
      Location:14353
      P2X; cation transporter protein
    5. XM_063270982.1XP_063127052.1  P2X purinoceptor 2 isoform X8

      UniProtKB/TrEMBL
      Q78DW4
    6. XM_006249515.5XP_006249577.1  P2X purinoceptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A140TAH4, A6J2A7
      Related
      ENSRNOP00000053533.5, ENSRNOT00000056694.6
      Conserved Domains (1) summary
      TIGR00863
      Location:14392
      P2X; cation transporter protein
    7. XM_006249516.5XP_006249578.1  P2X purinoceptor 2 isoform X4

      UniProtKB/TrEMBL
      Q78DW4
      Related
      ENSRNOP00000074992.2, ENSRNOT00000085661.3
      Conserved Domains (1) summary
      TIGR00863
      Location:14392
      P2X; cation transporter protein
    8. XM_006249517.5XP_006249579.1  P2X purinoceptor 2 isoform X5

      See identical proteins and their annotated locations for XP_006249579.1

      UniProtKB/TrEMBL
      A0A0G2K9G8, A6J2A8, Q78DW4
      Conserved Domains (1) summary
      TIGR00863
      Location:14380
      P2X; cation transporter protein
    9. XM_008769306.4XP_008767528.1  P2X purinoceptor 2 isoform X7

      See identical proteins and their annotated locations for XP_008767528.1

      UniProtKB/TrEMBL
      A6J2B1, A6J2B4
      Conserved Domains (1) summary
      cl02993
      Location:1293
      P2X_receptor; ATP P2X receptor

    RNA

    1. XR_005491585.2 RNA Sequence