Bcas3 BCAS3 microtubule associated cell migration factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcas3provided by MGI
Official Full Name: BCAS3 microtubule associated cell migration factorprovided by MGI
Primary source: MGI:MGI:2385848
See related: Ensembl:ENSMUSG00000059439 AllianceGenome:MGI:2385848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K20D4; Phaf2; rudhira; 1500019F07Rik; 2610028P08Rik
Summary: Predicted to enable several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Involved in cell-cell signaling; positive regulation of endothelial cell migration; and regulation of actin cytoskeleton organization. Located in cell leading edge; cell periphery; and cytoskeleton. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; hemolymphoid system; and yolk sac. Human ortholog(s) of this gene implicated in Hengel-Maroofian-Schols syndrome. Orthologous to human BCAS3 (BCAS3 microtubule associated cell migration factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 3.3), kidney adult (RPKM 3.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.34 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (85243611..85716884)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (85353110..85826058)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expressed at high levels in embryonic stem cells and is restricted to blood islands and the erythroid lineage during embryonic development
Title: Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Mit324 (e-PCR), detects polymorphism
- UniSTS:126537

D11Mit324.2 (e-PCR), detects polymorphism
- UniSTS:126538

D11Mit220 (e-PCR), detects polymorphism
- UniSTS:126422

Bcas3 (e-PCR), detects polymorphism
- UniSTS:478967

Bcas3 (e-PCR), detects polymorphism
- UniSTS:478968

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetyltransferase activator activity	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estrogen stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of catalytic activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: BCAS3 microtubule associated cell migration factor

Names: breast carcinoma amplified sequence 3; breast carcinoma-amplified sequence 3 homolog; protein rudhira

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166642.1 → NP_001160114.1 BCAS3 microtubule associated cell migration factor isoform b

See identical proteins and their annotated locations for NP_001160114.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform.

Source sequence(s)

AK032423, BC060690, BX323026, BY116917, CN711546

Consensus CDS

CCDS48873.1

UniProtKB/TrEMBL

Q0VF62, Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3
NM_001166643.1 → NP_001160115.1 BCAS3 microtubule associated cell migration factor isoform b

See identical proteins and their annotated locations for NP_001160115.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform.

Source sequence(s)

AL604024, BC060690, BC086693, BY116917

Consensus CDS

CCDS48873.1

UniProtKB/TrEMBL

Q0VF62, Q3TAC0

Related

ENSMUSP00000090496.4, ENSMUST00000092821.10

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3
NM_138681.4 → NP_619622.3 BCAS3 microtubule associated cell migration factor isoform a

See identical proteins and their annotated locations for NP_619622.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AK032423, BC060690, BX323026, BY116917, CN711546

Consensus CDS

CCDS25195.1

UniProtKB/Swiss-Prot

Q8CC16, Q8CCN5, Q9EPX3

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:581 → 764

BCAS3; Breast carcinoma amplified sequence 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

85243611..85716884

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245680.2 → XP_030101540.1 BCAS3 microtubule associated cell migration factor isoform X1

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_030245681.2 → XP_030101541.1 BCAS3 microtubule associated cell migration factor isoform X2

Conserved Domains (1) summary

pfam12490
Location:581 → 764

BCAS3; Breast carcinoma amplified sequence 3
XM_006532541.3 → XP_006532604.1 BCAS3 microtubule associated cell migration factor isoform X19

See identical proteins and their annotated locations for XP_006532604.1

UniProtKB/TrEMBL

Q0VF62, Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3
XM_036156433.1 → XP_036012326.1 BCAS3 microtubule associated cell migration factor isoform X2

Conserved Domains (1) summary

pfam12490
Location:581 → 764

BCAS3; Breast carcinoma amplified sequence 3
XM_030245679.2 → XP_030101539.1 BCAS3 microtubule associated cell migration factor isoform X1

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_036156436.1 → XP_036012329.1 BCAS3 microtubule associated cell migration factor isoform X11

UniProtKB/TrEMBL

B1AR74, Q3TAC0

Related

ENSMUSP00000103697.2, ENSMUST00000108062.8

Conserved Domains (1) summary

pfam12490
Location:581 → 764

BCAS3; Breast carcinoma amplified sequence 3
XM_030245687.1 → XP_030101547.1 BCAS3 microtubule associated cell migration factor isoform X8

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:581 → 764

BCAS3; Breast carcinoma amplified sequence 3
XM_030245689.1 → XP_030101549.1 BCAS3 microtubule associated cell migration factor isoform X17

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:581 → 764

BCAS3; Breast carcinoma amplified sequence 3
XM_006532540.3 → XP_006532603.1 BCAS3 microtubule associated cell migration factor isoform X15

See identical proteins and their annotated locations for XP_006532603.1

UniProtKB/Swiss-Prot

Q8CC16, Q8CCN5, Q9EPX3

UniProtKB/TrEMBL

Q3TAC0

Related

ENSMUSP00000074416.5, ENSMUST00000074875.11

Conserved Domains (1) summary

pfam12490
Location:581 → 764

BCAS3; Breast carcinoma amplified sequence 3
XM_030245685.2 → XP_030101545.1 BCAS3 microtubule associated cell migration factor isoform X5

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3
XM_017314342.2 → XP_017169831.1 BCAS3 microtubule associated cell migration factor isoform X14

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3
XM_030245688.1 → XP_030101548.1 BCAS3 microtubule associated cell migration factor isoform X12

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3
XM_036156438.1 → XP_036012331.1 BCAS3 microtubule associated cell migration factor isoform X20

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3
XM_030245678.2 → XP_030101538.1 BCAS3 microtubule associated cell migration factor isoform X1

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_036156434.1 → XP_036012327.1 BCAS3 microtubule associated cell migration factor isoform X4

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_030245684.2 → XP_030101544.1 BCAS3 microtubule associated cell migration factor isoform X2

Conserved Domains (1) summary

pfam12490
Location:581 → 764

BCAS3; Breast carcinoma amplified sequence 3
XM_030245682.2 → XP_030101542.1 BCAS3 microtubule associated cell migration factor isoform X3

Conserved Domains (1) summary

pfam12490
Location:534 → 762

BCAS3; Breast carcinoma amplified sequence 3
XM_011248810.4 → XP_011247112.1 BCAS3 microtubule associated cell migration factor isoform X21

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_030245686.2 → XP_030101546.1 BCAS3 microtubule associated cell migration factor isoform X5

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3
XM_006532542.5 → XP_006532605.1 BCAS3 microtubule associated cell migration factor isoform X22

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_006532537.5 → XP_006532600.1 BCAS3 microtubule associated cell migration factor isoform X7

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_006532539.4 → XP_006532602.1 BCAS3 microtubule associated cell migration factor isoform X13

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_006532536.5 → XP_006532599.1 BCAS3 microtubule associated cell migration factor isoform X6

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_006532538.4 → XP_006532601.1 BCAS3 microtubule associated cell migration factor isoform X10

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:594 → 777

BCAS3; Breast carcinoma amplified sequence 3
XM_036156435.1 → XP_036012328.1 BCAS3 microtubule associated cell migration factor isoform X9

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:534 → 762

BCAS3; Breast carcinoma amplified sequence 3
XM_036156437.1 → XP_036012330.1 BCAS3 microtubule associated cell migration factor isoform X18

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:534 → 762

BCAS3; Breast carcinoma amplified sequence 3
XM_017314343.1 → XP_017169832.1 BCAS3 microtubule associated cell migration factor isoform X16

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:534 → 762

BCAS3; Breast carcinoma amplified sequence 3
XM_036156439.1 → XP_036012332.1 BCAS3 microtubule associated cell migration factor isoform X20

UniProtKB/TrEMBL

Q3TAC0

Conserved Domains (1) summary

pfam12490
Location:521 → 749

BCAS3; Breast carcinoma amplified sequence 3