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    AXL AXL receptor tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 706123, updated on 17-Aug-2024

    Summary

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    Official Symbol
    AXLprovided by VGNC
    Official Full Name
    AXL receptor tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:70200
    See related
    Ensembl:ENSMMUG00000009145
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See AXL in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (40458531..40504554)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (37048805..37101142)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily A member 28, pseudogene Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene coiled-coil domain containing 97

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in natural killer cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase receptor UFO

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      40458531..40504554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028839773.1 → XP_028695606.1  tyrosine-protein kinase receptor UFO isoform X1

      UniProtKB/TrEMBL
      A0A8J8XYI9, G7NLI7, I0FHQ1
      Conserved Domains (5) summary
      cd05749
      Location:141 → 222
      Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
      cd00063
      Location:225 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:552 → 828
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      cd00096
      Location:53 → 119
      Ig; Immunoglobulin domain
      pfam00041
      Location:335 → 417
      fn3; Fibronectin type III domain

    2. XM_028839774.1 → XP_028695607.1  tyrosine-protein kinase receptor UFO isoform X2

      UniProtKB/TrEMBL
      A0A1D5Q330, A0A8J8XYI9, G7NLI7, I0FHQ1
      Related
      ENSMMUP00000042442.2, ENSMMUT00000074621.2
      Conserved Domains (5) summary
      cd05749
      Location:141 → 222
      Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
      cd00063
      Location:225 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:535 → 811
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      cd00096
      Location:53 → 119
      Ig; Immunoglobulin domain
      pfam00041
      Location:335 → 417
      fn3; Fibronectin type III domain

    3. XM_028839775.1 → XP_028695608.1  tyrosine-protein kinase receptor UFO isoform X3

      UniProtKB/TrEMBL
      F7E4X5, I0FHQ2
      Related
      ENSMMUP00000011992.4, ENSMMUT00000012790.4
      Conserved Domains (5) summary
      cd05749
      Location:141 → 222
      Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
      cd00063
      Location:225 → 328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05075
      Location:526 → 802
      PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
      cd00096
      Location:53 → 119
      Ig; Immunoglobulin domain
      pfam00041
      Location:335 → 417
      fn3; Fibronectin type III domain
    Nucleotide Protein
    Heading Accession and Version

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