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    SMAD5 SMAD family member 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712645, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SMAD5provided by VGNC
    Official Full Name
    SMAD family member 5provided by VGNC
    Primary source
    VGNC:VGNC:77813
    See related
    Ensembl:ENSMMUG00000000340
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SMAD5 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (133583841..133633013)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (133842405..133891609)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678911 Neighboring gene transforming growth factor beta induced Neighboring gene small integral membrane protein 32 Neighboring gene transient receptor potential cation channel subfamily C member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection. George J, et al. J Virol, 2015 Mar. PMID 25540365, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of microRNA miR-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFbeta receptor 2 (TGFbeta-R2) and SMAD5.
      Title: Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266315.1 → NP_001253244.1  mothers against decapentaplegic homolog 5

      See identical proteins and their annotated locations for NP_001253244.1

      Status: PROVISIONAL

      Source sequence(s)
      JU472412
      UniProtKB/TrEMBL
      A0A1D5Q5H1, A0A1D5RIS3, F6YMS3, G7MUE8
      Related
      ENSMMUP00000000461.2, ENSMMUT00000000497.4
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      133583841..133633013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015140869.2 → XP_014996355.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q5H1, A0A1D5RIS3, F6YMS3, G7MUE8
      Related
      ENSMMUP00000043287.2, ENSMMUT00000071258.2
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    2. XM_028849266.1 → XP_028705099.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q5H1, A0A1D5RIS3, F6YMS3, G7MUE8
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    3. XM_015140872.2 → XP_014996358.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q5H1, A0A1D5RIS3, F6YMS3, G7MUE8
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    4. XM_015140871.2 → XP_014996357.1  mothers against decapentaplegic homolog 5 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q5H1, A0A1D5RIS3, F6YMS3, G7MUE8
      Related
      ENSMMUP00000060217.2, ENSMMUT00000064339.2
      Conserved Domains (2) summary
      cd10490
      Location:10 → 133
      MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
      cd10497
      Location:265 → 465
      MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

    RNA

    1. XR_003730113.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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