skia v-ski avian sarcoma viral oncogene homolog a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: skiaprovided by ZNC
Official Full Name: v-ski avian sarcoma viral oncogene homolog aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990715-9
See related: Ensembl:ENSDARG00000042151 AllianceGenome:ZFIN:ZDB-GENE-990715-9
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: id:ibd1250
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within cardiac conduction; cartilage development; and regionalization. Located in nucleus. Is expressed in several structures, including brain; lens; presumptive diencephalon; solid lens vesicle; and tail bud. Used to study craniosynostosis. Orthologous to human SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (17395928..17516446, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (17360216..17480734, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

z43521b (e-PCR), detects polymorphism
- UniSTS:238685

G46595 (e-PCR)
- UniSTS:107396

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac conduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: v-ski avian sarcoma viral oncogene homolog a

Names: nuclear oncoprotein skia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130935.3 → NP_571010.3 v-ski avian sarcoma viral oncogene homolog a

Status: VALIDATED

Source sequence(s)

BX664713, CT573407, CU571083

UniProtKB/TrEMBL

Q1ECW8

Related

ENSDARP00000091440.4, ENSDART00000100667.5

Conserved Domains (3) summary

smart01046
Location:198 → 293

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:75 → 173

Ski_Sno; SKI/SNO/DAC family

cl25732
Location:532 → 705

SMC_N; RecF/RecN/SMC N terminal domain