Rilpl1 Rab interacting lysosomal protein-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rilpl1provided by MGI
Official Full Name: Rab interacting lysosomal protein-like 1provided by MGI
Primary source: MGI:MGI:1922945
See related: Ensembl:ENSMUSG00000029392 AllianceGenome:MGI:1922945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GOSPEL; 2900002H16Rik; 6330559I19Rik
Summary: Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Involved in epithelial cell morphogenesis and protein transport from ciliary membrane to plasma membrane. Located in centrosome and cilium. Is expressed in several structures, including brain; genitourinary system; gut; lens; and vertebral axis musculature. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 4. Orthologous to human RILPL1 (Rab interacting lysosomal protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 23.7), cortex adult (RPKM 9.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 63.62 cM; 5 F

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (124631143..124669684, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (124493080..124531441, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content by promoting protein removal from the primary cilium.
Title: The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content.
In intact mice, virally delivered GOSPEL selectively diminishes NMDA neurotoxicity. Thus, GOSPEL may physiologically regulate the viability of neurons and other cells.
Title: GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein transport from ciliary membrane to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RILP-like protein 1

Names: rab-interacting lysosomal-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417895.1 → NP_001404824.1 RILP-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC127313
NM_001417896.1 → NP_001404825.1 RILP-like protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC127313
NM_021430.3 → NP_067405.1 RILP-like protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC127313

Consensus CDS

CCDS19678.1

UniProtKB/Swiss-Prot

Q80WV8, Q9JJC6

Related

ENSMUSP00000050014.8, ENSMUST00000062153.12

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:28 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

124631143..124669684 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248246.4 → XP_011246548.1 RILP-like protein 1 isoform X3

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:28 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_006530491.5 → XP_006530554.1 RILP-like protein 1 isoform X4

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:28 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_011248245.4 → XP_011246547.1 RILP-like protein 1 isoform X2

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:28 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein
XM_036165584.1 → XP_036021477.1 RILP-like protein 1 isoform X6

Conserved Domains (3) summary

TIGR02169
Location:76 → 322

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam09744
Location:27 → 174

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam11461
Location:299 → 351

RILP; Rab interacting lysosomal protein