gadd45aa growth arrest and DNA-damage-inducible, alpha, a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gadd45aaprovided by ZNC
Official Full Name: growth arrest and DNA-damage-inducible, alpha, aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1501
See related: Ensembl:ENSDARG00000043581 AllianceGenome:ZFIN:ZDB-GENE-040426-1501
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gadd45al; zgc:65993; zgc:77480
Summary: Acts upstream of or within paraxial mesoderm development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; endoderm; eye; otic placode; and solid lens vesicle. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (10280667..10284572)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (10497068..10500973)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Naringenin also attenuated hepatic apoptosis in larvae as detected by TUNEL staining, consistent with the expression of critical biomarkers of endoplasmic reticulum stress and of DNA damage genes (chop, gadd45alphaa and edem1). The present study showed that naringenin inhibited alcohol-induced liver steatosis and injury in zebrafish larvae by reducing apoptosis and DNA damage and by harmonizing alcohol and lipid metabo...
Title: Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae.
these results suggest that maternal Prmt6 is essential to early zebrafish development by directly repressing gadd45alphaa.
Title: Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within paraxial mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth arrest and DNA-damage-inducible, alpha, a

Names: gadd45alpha; growth arrest and DNA damage 45 alpha; growth arrest and DNA-damage-inducible, alpha like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200576.2 → NP_956870.2 growth arrest and DNA-damage-inducible, alpha, a

Status: VALIDATED

Source sequence(s)

CU693482, EH446990

UniProtKB/TrEMBL

A0A8M1PBG0, F1R8Z0

Related

ENSDARP00000063995.3, ENSDART00000063996.4

Conserved Domains (1) summary

pfam01248
Location:20 → 102

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family