Vti1a vesicle transport through interaction with t-SNAREs 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vti1aprovided by MGI
Official Full Name: vesicle transport through interaction with t-SNAREs 1Aprovided by MGI
Primary source: MGI:MGI:1855699
See related: Ensembl:ENSMUSG00000024983 AllianceGenome:MGI:1855699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vti1; MVti1; MVti1a; Vti1-rp2; 1110014F16Rik; 1110018K19Rik; 4921537J05Rik
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; endosomal transport; and voluntary musculoskeletal movement. Predicted to be located in several cellular components, including autophagosome; cytoplasmic vesicle; and neuronal cell body. Predicted to be part of SNARE complex. Predicted to be active in several cellular components, including Golgi apparatus; cytoplasmic vesicle membrane; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human VTI1A (vesicle transport through interaction with t-SNAREs 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 51.35 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (55304489..55615893)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (55316030..55627461)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
Title: Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.
Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
Title: Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
In adrenal chromaffin cells, vti1a localizes to a compartment near the trans-Golgi-network, but is absent from secretory granules.Vti1a is not required for final fusion of dense-core vesicles, but is needed for their generation.
Title: The SNARE protein vti1a functions in dense-core vesicle biogenesis.
VTI1A, a vesicular transport associated factor is a novel regulator of hepatitis C virus release but not replication.
Title: Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28γ knockout in HCV pathogenesis: a network-based study.
Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development
Title: Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-12c5 (e-PCR)
- UniSTS:258313

D19Mit104 (e-PCR), detects polymorphism
- UniSTS:128319

D19Mit35 (e-PCR), detects polymorphism
- UniSTS:128376

NoName (e-PCR)
- UniSTS:237977

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISO Inferred from Sequence Orthology more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle to endosome fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle fusion with Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion with Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in vesicle fusion with Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in voluntary musculoskeletal movement	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in ER to Golgi transport vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: vesicle transport through interaction with t-SNAREs homolog 1A

Names: vesicle transport through interaction with t-SNAREs 1 homolog; vesicle transport v-SNARE protein Vti1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293685.1 → NP_001280614.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform 1

See identical proteins and their annotated locations for NP_001280614.1

Status: VALIDATED

Source sequence(s)

AC133100, BB767664, BC089321

Consensus CDS

CCDS89416.1

UniProtKB/TrEMBL

Q5FWJ7

Related

ENSMUSP00000153629.2, ENSMUST00000223690.2

Conserved Domains (2) summary

cd15891
Location:129 → 190

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
NM_001293686.1 → NP_001280615.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform 3

Status: VALIDATED

Source sequence(s)

AC133100, AK028646, AK148281, BB767664, BC089321

UniProtKB/Swiss-Prot

O89116

UniProtKB/TrEMBL

Q5FWJ7

Conserved Domains (2) summary

cd15891
Location:122 → 183

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 89

V-SNARE; Vesicle transport v-SNARE protein N-terminus
NM_001360431.1 → NP_001347360.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform 4

Status: VALIDATED

Source sequence(s)

AC133100, AC166100, CO430297

Conserved Domains (2) summary

cd15891
Location:129 → 190

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
NM_001360432.1 → NP_001347361.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform 5

Status: VALIDATED

Source sequence(s)

AC133100, AK135463

Consensus CDS

CCDS89417.1

UniProtKB/TrEMBL

A0A286YDF2

Related

ENSMUSP00000153392.2, ENSMUST00000225529.2

Conserved Domains (2) summary

cd15891
Location:122 → 183

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
NM_016862.4 → NP_058558.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform 2

See identical proteins and their annotated locations for NP_058558.1

Status: VALIDATED

Source sequence(s)

AC133100, AK028646, BB767664, BC089321

Consensus CDS

CCDS29910.1

UniProtKB/Swiss-Prot

O89116, Q545P9

Related

ENSMUSP00000093644.3, ENSMUST00000095950.3

Conserved Domains (2) summary

cd15891
Location:122 → 183

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

55304489..55615893

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161635.1 → XP_036017528.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X12

Conserved Domains (2) summary

pfam05008
Location:12 → 89

V-SNARE; Vesicle transport v-SNARE protein N-terminus

cl22856
Location:122 → 142

SNARE; SNARE motif
XM_036161636.1 → XP_036017529.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X14

Conserved Domains (2) summary

pfam05008
Location:12 → 89

V-SNARE; Vesicle transport v-SNARE protein N-terminus

cl22856
Location:122 → 142

SNARE; SNARE motif
XM_017318251.3 → XP_017173740.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X3

Conserved Domains (2) summary

cd15891
Location:129 → 190

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_030250990.2 → XP_030106850.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X4

Conserved Domains (2) summary

cd15891
Location:122 → 183

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_006527192.5 → XP_006527255.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X9

See identical proteins and their annotated locations for XP_006527255.1

Conserved Domains (2) summary

cd15891
Location:129 → 190

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_006527191.4 → XP_006527254.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X8

See identical proteins and their annotated locations for XP_006527254.1

Conserved Domains (2) summary

cd15891
Location:129 → 190

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_006527188.4 → XP_006527251.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X7

Conserved Domains (2) summary

cd15891
Location:129 → 190

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_036161633.1 → XP_036017526.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X10

Conserved Domains (2) summary

cd15891
Location:122 → 183

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 89

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_036161630.1 → XP_036017523.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X5

Conserved Domains (2) summary

cd15891
Location:129 → 190

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 89

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_036161631.1 → XP_036017524.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X6

Conserved Domains (2) summary

cd15891
Location:122 → 183

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 89

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_006527184.5 → XP_006527247.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X1

Conserved Domains (2) summary

cd15891
Location:129 → 190

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_006527185.5 → XP_006527248.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X2

Conserved Domains (2) summary

cd15891
Location:122 → 183

SNARE_Vti1a; SNARE motif of Vti1b-like

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_036161634.1 → XP_036017527.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X11

Conserved Domains (2) summary

pfam05008
Location:12 → 89

V-SNARE; Vesicle transport v-SNARE protein N-terminus

cl22856
Location:129 → 149

SNARE; SNARE motif
XM_006527198.5 → XP_006527261.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X15

Conserved Domains (1) summary

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus
XM_006527196.5 → XP_006527259.1 vesicle transport through interaction with t-SNAREs homolog 1A isoform X13

Conserved Domains (2) summary

pfam05008
Location:12 → 90

V-SNARE; Vesicle transport v-SNARE protein N-terminus

cl22856
Location:129 → 149

SNARE; SNARE motif