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    LYRM9 LYR motif containing 9 [ Homo sapiens (human) ]

    Gene ID: 201229, updated on 27-Nov-2024

    Summary

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    Official Symbol
    LYRM9provided by HGNC
    Official Full Name
    LYR motif containing 9provided by HGNC
    Primary source
    HGNC:HGNC:27314
    See related
    Ensembl:ENSG00000232859 AllianceGenome:HGNC:27314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSD24; C17orf108
    Summary
    Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.9), brain (RPKM 12.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LYRM9 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (27878358..27893365, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (28819756..28834759, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26205384..26220391, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26110033-26110532 Neighboring gene nitric oxide synthase 2 Neighboring gene NOS2 5' regulatory region Neighboring gene uncharacterized LOC124903961 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:26208991-26209681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26215109-26216060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26216061-26217012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8331 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:26241118-26241431 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:26242505-26243362 Neighboring gene long intergenic non-protein coding RNA 1992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11915 Neighboring gene uncharacterized LOC124903962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26284095-26284956 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:26286038-26286747 Neighboring gene Sharpr-MPRA regulatory region 4282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11916 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1404 Neighboring gene MPRA-validated peak2774 silencer Neighboring gene uncharacterized LOC124900402

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly. Dibley MG, et al. Mol Cell Proteomics, 2020 Jan. PMID 31666358, Free PMC Article
    2. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. van der Valk RJ, et al. J Allergy Clin Immunol, 2014 Jul. PMID 24315451, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    LYR motif-containing protein 9
    Names
    UPF0631 protein C17orf108

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076680.3 → NP_001070148.1  LYR motif-containing protein 9

      See identical proteins and their annotated locations for NP_001070148.1

      Status: VALIDATED

      Source sequence(s)
      AC005697, AI804732, DB474433, DR155808
      Consensus CDS
      CCDS45631.1
      UniProtKB/Swiss-Prot
      A6NJT7, A8MSI8, Q6X7B8
      UniProtKB/TrEMBL
      D6RAR2
      Related
      ENSP00000368396.3, ENST00000379102.8
      Conserved Domains (1) summary
      pfam13232
      Location:11 → 70
      Complex1_LYR_1; Complex1_LYR-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      27878358..27893365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435563.1 → XP_047291519.1  LYR motif-containing protein 9 isoform X3

      UniProtKB/Swiss-Prot
      A6NJT7, A8MSI8, Q6X7B8

    2. XM_047435562.1 → XP_047291518.1  LYR motif-containing protein 9 isoform X3

      UniProtKB/Swiss-Prot
      A6NJT7, A8MSI8, Q6X7B8
      Related
      ENSP00000368397.2, ENST00000379103.7

    3. XM_024450636.2 → XP_024306404.1  LYR motif-containing protein 9 isoform X2

      Conserved Domains (1) summary
      pfam05347
      Location:37 → 95
      Complex1_LYR; Complex 1 protein (LYR family)

    4. XM_011524491.4 → XP_011522793.1  LYR motif-containing protein 9 isoform X1

      Conserved Domains (1) summary
      pfam13232
      Location:37 → 96
      Complex1_LYR_1; Complex1_LYR-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      28819756..28834759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315366.1 → XP_054171341.1  LYR motif-containing protein 9 isoform X3

      UniProtKB/Swiss-Prot
      A6NJT7, A8MSI8, Q6X7B8

    2. XM_054315365.1 → XP_054171340.1  LYR motif-containing protein 9 isoform X3

      UniProtKB/Swiss-Prot
      A6NJT7, A8MSI8, Q6X7B8

    3. XM_054315364.1 → XP_054171339.1  LYR motif-containing protein 9 isoform X3

      UniProtKB/Swiss-Prot
      A6NJT7, A8MSI8, Q6X7B8

    4. XM_054315363.1 → XP_054171338.1  LYR motif-containing protein 9 isoform X2

    5. XM_054315362.1 → XP_054171337.1  LYR motif-containing protein 9 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MSI8.2 GenPept UniProtKB/Swiss-Prot:A8MSI8

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