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    IFIT2 interferon induced protein with tetratricopeptide repeats 2 [ Homo sapiens (human) ]

    Gene ID: 3433, updated on 10-Dec-2024

    Summary

    Official Symbol
    IFIT2provided by HGNC
    Official Full Name
    interferon induced protein with tetratricopeptide repeats 2provided by HGNC
    Primary source
    HGNC:HGNC:5409
    See related
    Ensembl:ENSG00000119922 MIM:147040; AllianceGenome:HGNC:5409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; ISG-54; GARG-39; IFI-54K; ISG-54K; ISG-54 K
    Summary
    Enables RNA binding activity. Involved in antiviral innate immune response and positive regulation of apoptotic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 19.8), spleen (RPKM 15.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IFIT2 in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (89302046..89309271)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (90185914..90193139)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91061803..91069028)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase A, lysosomal acid type Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:90994669-90995170 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:90995171-90995670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3738 Neighboring gene uncharacterized LOC124902477 Neighboring gene uncharacterized LOC105378419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3741 Neighboring gene uncharacterized LOC101926887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2592 Neighboring gene Sharpr-MPRA regulatory region 6014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3744 Neighboring gene interferon induced protein with tetratricopeptide repeats 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3745 Neighboring gene interferon induced protein with tetratricopeptide repeats 6, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-induced protein with tetratricopeptide repeats 2 (IFIT2; IFI54) in immature dendritic cells and monocyte-derived macrophages PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells PubMed
    vpr HIV-1 Vpr upregulates the gene expression of IFIT1 in human monocyte-derived dendritic cells PubMed
    Vpu vpu The expression of IFIT2 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon-induced protein with tetratricopeptide repeats 2
    Names
    Interferon, alpha-inducible protein (MW 54kD)
    interferon-induced 54 kDa protein
    interferon-induced protein 54

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001547.5NP_001538.4  interferon-induced protein with tetratricopeptide repeats 2

      See identical proteins and their annotated locations for NP_001538.4

      Status: VALIDATED

      Source sequence(s)
      AA143609, AA765174, AL353751, BC005987, EB387611
      Consensus CDS
      CCDS41548.1
      UniProtKB/Swiss-Prot
      P09913, Q5T767
      UniProtKB/TrEMBL
      A0A7P0T8B3, B4DTZ5
      Related
      ENSP00000360891.3, ENST00000371826.4
      Conserved Domains (2) summary
      sd00006
      Location:248275
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:51112
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      89302046..89309271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      90185914..90193139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)