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    Btnd Biotinidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btndprovided by FlyBase
    Official Full Name
    Biotinidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029848
    Locus tag
    Dmel_CG3599
    See related
    AllianceGenome:FB:FBgn0029848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Btd; BTD; CG3599; CT12113; Dmel\CG3599
    Summary
    Enables biotinidase activity. Involved in chromatin organization. Is expressed in adult main segment of Malpighian tubule. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Btnd in Genome Data Viewer
    Location:
    5E1-5E1; 1-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6217268..6219327, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6111301..6113360, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene vanin-like Neighboring gene uncharacterized protein Neighboring gene ER GDP-fucose transporter Neighboring gene spaghetti squash

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of biotindase in mammals and identification of the putative biotinidase gene in Drosophila melanogaster. Swango KL, et al. Mol Genet Metab, 2001 Dec. PMID 11749055
    2. Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance. Camporeale G, et al. J Nutr, 2006 Nov. PMID 17056793, Free PMC Article
    3. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Lohr KM, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33318181, Free PMC Article
    4. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Fergestad T, et al. Genetics, 2006 Jul. PMID 16648587, Free PMC Article
    5. Metabolic pathways modulate the neuronal toxicity associated with fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Hum Mol Genet, 2019 Mar 15. PMID 30476102, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conserved seq in mammals, identification of putative gene for biotinidase in Drosophila
      Title: Conservation of biotindase in mammals and identification of the putative biotinidase gene in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables biotinidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    biotinidase
    Names
    Btnd-PA
    CG3599-PA
    NP_572298.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6217268..6219327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132070.3 → NP_572298.1  biotinidase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W430
      Related
      FBpp0070843
      Conserved Domains (1) summary
      cd07567
      Location:29 → 308
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W430 Q9W430

    Gene LinkOut

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