Ccar1 cell division cycle and apoptosis regulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccar1provided by MGI
Official Full Name: cell division cycle and apoptosis regulator 1provided by MGI
Primary source: MGI:MGI:1914750
See related: Ensembl:ENSMUSG00000020074 AllianceGenome:MGI:1914750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Carp1; 2610511G16Rik; 9430036H15Rik
Summary: Enables transcription coactivator activity. Predicted to be involved in positive regulation of cell migration; positive regulation of cell population proliferation; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in nuclear envelope lumen. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 29.0), CNS E14 (RPKM 18.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.47 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (62579707..62628147, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (62743928..62792368, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of CCAR1 compromised adipogenesis in cell culture and GR-mediated chromatin remodeling of PPARgamma gene enhancer elements.
Title: Coregulator cell cycle and apoptosis regulator 1 (CCAR1) positively regulates adipocyte differentiation through the glucocorticoid signaling pathway.
CCAR1 and CoCoA are a bypass between GATA1 and the MED1 subunit of Mediator
Title: CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function.
studies identified CARP-1 for the first time in osteoblasts and suggest its potential role in PTH signaling and bone anabolic action
Title: Cell cycle and apoptosis regulatory protein (CARP)-1 is expressed in osteoblasts and regulated by PTH.
necdin exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1)
Title: Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division cycle and apoptosis regulator protein 1

Names: CARP-1; cell cycle and apoptosis regulatory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429504.1 → NP_001416433.1 cell division cycle and apoptosis regulator protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC122539

UniProtKB/Swiss-Prot

Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
NM_001429505.1 → NP_001416434.1 cell division cycle and apoptosis regulator protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC122539

UniProtKB/Swiss-Prot

Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5
NM_001429506.1 → NP_001416435.1 cell division cycle and apoptosis regulator protein 1 isoform b

Status: VALIDATED

Source sequence(s)

AC122539
NM_001429507.1 → NP_001416436.1 cell division cycle and apoptosis regulator protein 1 isoform b

Status: VALIDATED

Source sequence(s)

AC122539
NM_001429508.1 → NP_001416437.1 cell division cycle and apoptosis regulator protein 1 isoform b

Status: VALIDATED

Source sequence(s)

AC122539
NM_001429509.1 → NP_001416438.1 cell division cycle and apoptosis regulator protein 1 isoform b

Status: VALIDATED

Source sequence(s)

AC122539
NM_001429510.1 → NP_001416439.1 cell division cycle and apoptosis regulator protein 1 isoform c

Status: VALIDATED

Source sequence(s)

AC122539
NM_001429511.1 → NP_001416440.1 cell division cycle and apoptosis regulator protein 1 isoform c

Status: VALIDATED

Source sequence(s)

AC122539
NM_026201.4 → NP_080477.1 cell division cycle and apoptosis regulator protein 1 isoform a

See identical proteins and their annotated locations for NP_080477.1

Status: VALIDATED

Source sequence(s)

AC122539

Consensus CDS

CCDS35922.1

UniProtKB/Swiss-Prot

Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5

Related

ENSMUSP00000151895.2, ENSMUST00000219527.2

Conserved Domains (5) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PRK10927
Location:184 → 303

PRK10927; cell division protein FtsN

TIGR04523
Location:1034 → 1141

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam14443
Location:479 → 598

DBC1

pfam14444
Location:145 → 201

S1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

62579707..62628147 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513997.4 → XP_006514060.1 cell division cycle and apoptosis regulator protein 1 isoform X2

UniProtKB/Swiss-Prot

Q8CH18

Conserved Domains (4) summary

PRK10927
Location:184 → 303

PRK10927; cell division protein FtsN

TIGR04523
Location:972 → 1079

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam14443
Location:476 → 601

DBC1

pfam14444
Location:145 → 201

S1-like
XM_036155963.1 → XP_036011856.1 cell division cycle and apoptosis regulator protein 1 isoform X2

Conserved Domains (4) summary

PRK10927
Location:184 → 303

PRK10927; cell division protein FtsN

TIGR04523
Location:972 → 1079

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam14443
Location:476 → 601

DBC1

pfam14444
Location:145 → 201

S1-like
XM_006513996.4 → XP_006514059.1 cell division cycle and apoptosis regulator protein 1 isoform X1

Conserved Domains (5) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PRK10927
Location:184 → 303

PRK10927; cell division protein FtsN

TIGR04523
Location:1034 → 1141

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam14443
Location:479 → 598

DBC1

pfam14444
Location:145 → 201

S1-like
XM_011243537.4 → XP_011241839.1 cell division cycle and apoptosis regulator protein 1 isoform X1

Related

ENSMUSP00000020268.6, ENSMUST00000020268.7

Conserved Domains (5) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PRK10927
Location:184 → 303

PRK10927; cell division protein FtsN

TIGR04523
Location:1034 → 1141

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam14443
Location:479 → 598

DBC1

pfam14444
Location:145 → 201

S1-like
XM_006513994.5 → XP_006514057.1 cell division cycle and apoptosis regulator protein 1 isoform X1

See identical proteins and their annotated locations for XP_006514057.1

UniProtKB/Swiss-Prot

Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5

Conserved Domains (5) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PRK10927
Location:184 → 303

PRK10927; cell division protein FtsN

TIGR04523
Location:1034 → 1141

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam14443
Location:479 → 598

DBC1

pfam14444
Location:145 → 201

S1-like
XM_006513995.4 → XP_006514058.1 cell division cycle and apoptosis regulator protein 1 isoform X1

See identical proteins and their annotated locations for XP_006514058.1

UniProtKB/Swiss-Prot

Q05BR1, Q05DK6, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q8CH18, Q9CSR5

Conserved Domains (5) summary

smart00513
Location:634 → 667

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PRK10927
Location:184 → 303

PRK10927; cell division protein FtsN

TIGR04523
Location:1034 → 1141

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam14443
Location:479 → 598

DBC1

pfam14444
Location:145 → 201

S1-like