Pnsl5 cyclophilin 20-2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: Pnsl5
Official Full Name: cyclophilin 20-2
Primary source: TAIR:AT5G13120
Locus tag: AT5G13120
See related: Araport:AT5G13120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA CYCLOPHILIN 20-2; ATCYP20-2; cyclophilin 20-2; CYP20-2; Photosynthetic NDH subcomplex L 5; T19L5.80; T19L5_80
Summary: Encodes a lumenal cyclophilin with peptidyl-prolyl isomerase activity that is associated with the NAD(P)H dehydrogenase complex in stromal regions of the thylakoid membrane. It is likely to be important for the accumulation of the hydrophobic domain of the NAD(P)H dehydrogenase complex. This complex is associated with PSI and is responsible for the reduction of plastoquinone.
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Genomic context

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See Pnsl5 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (4162374..4164923, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that conformational changes of BRASSINAZOLE-RESISTANT1 (BZR1), mediated by cyclophilin (CYP20-2), may directly regulate the expression of FLOWERING LOCUS D (FLD) to influence flowering.
Title: The cyclophilin CYP20-2 modulates the conformation of BRASSINAZOLE-RESISTANT1, which binds the promoter of FLOWERING LOCUS D to regulate flowering in Arabidopsis.
Double mutant plants disrupted AtCYP20-2 and AtFKBP13 did not show any phenotypic changes compared with wild-type plants, while peptidyl-prolyl isomerase activity activity was almost completely abolished from the mutant thylakoid lumen.
Title: Peptidyl-prolyl isomerase activity in chloroplast thylakoid lumen is a dispensable function of immunophilins in Arabidopsis thaliana.
findings show that AtCYP20-2 is associated with a thylakoid protein complex, the NAD(P)H dehydrogenase (NDH) complex
Title: AtCYP20-2 is an auxiliary protein of the chloroplast NAD(P)H dehydrogenase complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203370.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within NAD(P)H dehydrogenase complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stromal thylakoid	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast thylakoid	HDA more info	PubMed
located_in chloroplast thylakoid lumen	HDA more info	PubMed
located_in chloroplast thylakoid membrane	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed
located_in thylakoid lumen	HDA more info	PubMed

General protein information

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Preferred Names: cyclophilin 20-2

NP_001190299.1

cyclophilin 20-2 (CYP20-2); CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 4 (TAIR:AT3G62030.1).

NP_196816.1

cyclophilin 20-2 (CYP20-2); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: protein folding, NAD(P)H dehydrogenase complex assembly; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 4 (TAIR:AT3G62030.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

4162374..4164923 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_121315.3 → NP_196816.1 cyclophilin 20-2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196816.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4K2G0, Q53YK9, Q8L9L5, Q9ASS6, Q9FY98

UniProtKB/TrEMBL

A0A178UN74, A0A5S9Y4C9

Conserved Domains (1) summary

cd01926
Location:90 → 252

cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
NM_001203370.1 → NP_001190299.1 cyclophilin 20-2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190299.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9ASS6

Conserved Domains (1) summary

cd01926
Location:86 → 248

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...