RAPTOR2 regulatory-associated protein of TOR 2 (RAPTOR2) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RAPTOR2
Official Full Name: regulatory-associated protein of TOR 2 (RAPTOR2)
Primary source: TAIR:AT5G01770
Locus tag: AT5G01770
See related: Araport:AT5G01770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRAPTOR1A; RAPTOR1A; T20L15.40; T20L15_40
Summary: Encodes one of two Arabidopsis RAPTOR/KOG1 homologs. RAPTOR proteins are binding partners of the target of rapamycin kinase that is present in all eukaryotes and play a central role in the stimulation of cell growth and metabolism in response to nutrients. Mutations in this gene have no visible effects on embryo or plant development.
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Genomic context

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See RAPTOR2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 23

Sequence:: Chromosome: 5; NC_003076.8 (293675..302015, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterization of the two Arabidopsis orthologs of Raptor (AtRaptor1 and 2); disruption of the AtRaptor2 gene, which is expressed at a lower level than AtRaptor1, has no visible effects on embryo and plant development[AtRaptor2]
Title: An Arabidopsis homolog of RAPTOR/KOG1 is essential for early embryo development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_120255.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Process	Evidence Code	Pubs
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of shoot apical meristem identity	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: regulatory-associated protein of TOR 2 (RAPTOR2)

NP_195797.3

RAPTOR2 (RAPTOR2); FUNCTIONS IN: binding, nucleotide binding; INVOLVED IN: cell growth; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), WD40 repeat (InterPro:IPR001680), Regulatory associated protein of TOR (InterPro:IPR004083), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), Armadillo-type fold (InterPro:IPR016024), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: HEAT repeat; WD domain, G-beta repeat protein protein (TAIR:AT3G08850.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

293675..302015 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001342618.1 → NP_001330424.1 regulatory-associated protein of TOR 2 (RAPTOR2) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UA01, A0A1P8BAT3, A0A5S9Y0K5
NM_001342617.1 → NP_001330425.1 regulatory-associated protein of TOR 2 (RAPTOR2) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178U8C2, A0A1P8BAT5
NM_001342619.1 → NP_001330427.1 regulatory-associated protein of TOR 2 (RAPTOR2) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UA01, A0A1P8BAS5, A0A5S9Y0K5
NM_001342620.1 → NP_001330426.1 regulatory-associated protein of TOR 2 (RAPTOR2) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UA01, A0A1P8BAR8, A0A5S9Y0K5
NM_120255.3 → NP_195797.3 regulatory-associated protein of TOR 2 (RAPTOR2) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195797.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LZW9

UniProtKB/TrEMBL

A0A178UA01, A0A5S9Y0K5

Conserved Domains (4) summary

COG2319
Location:966 → 1320

WD40; WD40 repeat [General function prediction only]

pfam14538
Location:99 → 246

Raptor_N; Raptor N-terminal CASPase like domain

sd00039
Location:1124 → 1158

7WD40; WD40 repeat [structural motif]

cl02567
Location:1018 → 1327

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...