Parp2 poly (ADP-ribose) polymerase family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp2provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 2provided by MGI
Primary source: MGI:MGI:1341112
See related: Ensembl:ENSMUSG00000036023 AllianceGenome:MGI:1341112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD2; Adprt2; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2
Summary: Enables NAD+-protein poly-ADP-ribosyltransferase activity. Involved in decidualization. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 20.7), liver E14 (RPKM 15.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 26.25 cM; 14 C1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (51045347..51058758)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (50807897..50821301)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes.
Title: PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes.
PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization.
Title: PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization.
Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
Title: Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
miRNA-149 targets PARP-2 in endometrial epithelial and stromal cells to regulate the trophoblast attachment process.
Title: miRNA-149 targets PARP-2 in endometrial epithelial and stromal cells to regulate the trophoblast attachment process.
Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.
Title: Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.
Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
Title: Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8.
Title: Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8.
Hsa-circ-0068566 inhibited the development of myocardial ischemia reperfusion injury by regulating hsa-miR-6322/PARP2 signal pathway.
Title: Hsa-circ-0068566 inhibited the development of myocardial ischemia reperfusion injury by regulating hsa-miR-6322/PARP2 signal pathway.
Silencing of PARP2 Blocks Autophagic Degradation.
Title: Silencing of PARP2 Blocks Autophagic Degradation.
Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice.
Title: Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126406 (e-PCR)
- UniSTS:163114

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

UniSTS:492996 (e-PCR)
- UniSTS:492996

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD DNA ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD DNA ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BS6 serine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H3S10 serine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein-serine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-serine ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables nucleosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables poly-ADP-D-ribose binding	IEA Inferred from Electronic Annotation more info
enables poly-ADP-D-ribose binding	ISO Inferred from Sequence Orthology more info
enables poly-ADP-D-ribose modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables poly-ADP-D-ribose modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in DNA ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	TAS Traceable Author Statement more info	PubMed
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in DNA repair-dependent chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within base-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in decidualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in hippocampal neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in hippocampal neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxygen-glucose deprivation	IEA Inferred from Electronic Annotation more info
involved_in response to oxygen-glucose deprivation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: poly [ADP-ribose] polymerase 2

Names: ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2; ADP-ribosyltransferase diphtheria toxin-like 2; DNA ADP-ribosyltransferase PARP2; NAD(+) ADP-ribosyltransferase 2; poly[ADP-ribose] synthase 2; poly[ADP-ribose] synthetase 2; protein poly-ADP-ribosyltransferase PARP2

NP_001409012.1

EC 2.4.2.30

NP_001409013.1

EC 2.4.2.30

NP_001409014.1

EC 2.4.2.30

NP_033762.1

EC 2.4.2.30

XP_036014293.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001422083.1 → NP_001409012.1 poly [ADP-ribose] polymerase 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC027184
NM_001422084.1 → NP_001409013.1 poly [ADP-ribose] polymerase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC027184
NM_001422085.1 → NP_001409014.1 poly [ADP-ribose] polymerase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC027184
NM_009632.4 → NP_033762.1 poly [ADP-ribose] polymerase 2 isoform 1

See identical proteins and their annotated locations for NP_033762.1

Status: VALIDATED

Source sequence(s)

AC027184

Consensus CDS

CCDS27025.1

UniProtKB/Swiss-Prot

O88554, Q99N29

Related

ENSMUSP00000048877.6, ENSMUST00000036126.7

Conserved Domains (3) summary

cd08003
Location:86 → 188

WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases

cd01437
Location:207 → 552

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:341 → 553

PARP; Poly(ADP-ribose) polymerase catalytic domain

RNA

NR_185484.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC027184
NR_185485.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC027184

Related

ENSMUST00000228672.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

51045347..51058758

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158400.1 → XP_036014293.1 poly [ADP-ribose] polymerase 2 isoform X2

Conserved Domains (1) summary

cd01437
Location:21 → 281

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...