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    ced-6 Cell death protein 6 [ Caenorhabditis elegans ]

    Gene ID: 175773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ced-6
    Official Full Name
    Cell death protein 6
    Primary source
    WormBase:WBGene00000420
    Locus tag
    CELE_F56D2.7
    See related
    AllianceGenome:WB:WBGene00000420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables clathrin adaptor activity and scavenger receptor binding activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and positive regulation of distal tip cell migration. Located in cytoplasmic side of plasma membrane and phagocytic vesicle. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ced-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5595771..5598061)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cytochrome b-c1 complex subunit 1, mitochondrial;Peptidase M16 C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene WD repeat-containing protein 37 Neighboring gene MADF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells. Su HP, et al. J Biol Chem, 2000 Mar 31. PMID 10734103
    2. Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Liu QA, et al. Curr Biol, 1999 Nov 18. PMID 10574771
    3. CED-6/GULP and components of the clathrin-mediated endocytosis machinery act redundantly to correctly display CED-1 on the cell membrane in Caenorhabditis elegans. Harders RH, et al. G3 (Bethesda), 2024 Jul 8. PMID 38696649, Free PMC Article
    4. Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans. Peña-Ramos O, et al. Elife, 2022 Jan 4. PMID 34982028, Free PMC Article
    5. Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Wang X, et al. Nat Cell Biol, 2010 Jul. PMID 20526330, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scavenger receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process involved in development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic process involved in development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in left/right axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process involved in development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process involved in development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of distal tip cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of engulfment of apoptotic cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cell death protein 6
    NP_498203.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5595771..5598061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065802.10 → NP_498203.2  Cell death protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498203.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01421, O76337
      Conserved Domains (1) summary
      cd01273
      Location:48 → 196
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76337.1

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