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    GPR142 G protein-coupled receptor 142 [ Homo sapiens (human) ]

    Gene ID: 350383, updated on 10-Dec-2024

    Summary

    Official Symbol
    GPR142provided by HGNC
    Official Full Name
    G protein-coupled receptor 142provided by HGNC
    Primary source
    HGNC:HGNC:20088
    See related
    Ensembl:ENSG00000257008 MIM:609046; AllianceGenome:HGNC:20088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR2; GPRg1b
    Summary
    GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in stomach (RPKM 1.1), spleen (RPKM 0.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GPR142 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74367506..74372600)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75258167..75263271)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72363645..72368739)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 19 Neighboring gene uncharacterized LOC107985078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72348389-72348919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72353094-72353966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8930 Neighboring gene BTB domain containing 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72364259-72365247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8931 Neighboring gene uncharacterized LOC124904055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72382905-72383799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390282-72390782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390783-72391283 Neighboring gene Sharpr-MPRA regulatory region 691 Neighboring gene RNA, 5S ribosomal pseudogene 448

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    probable G-protein coupled receptor 142
    Names
    G-protein coupled receptor 142 long form
    G-protein coupled receptor PGR2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331076.1NP_001318005.1  probable G-protein coupled receptor 142 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AY288421, BC143807
      Consensus CDS
      CCDS92387.1
      UniProtKB/TrEMBL
      A0A1C9J7K7, J3QSD0
      Related
      ENSP00000464632.2, ENST00000582579.6
    2. NM_001331077.1NP_001318006.1  probable G-protein coupled receptor 142 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AY288421, DY312809, DY312859
      Consensus CDS
      CCDS92387.1
      UniProtKB/TrEMBL
      A0A1C9J7K7, J3QSD0
    3. NM_181790.1NP_861455.1  probable G-protein coupled receptor 142 isoform a

      See identical proteins and their annotated locations for NP_861455.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AY288421
      Consensus CDS
      CCDS11698.1
      UniProtKB/Swiss-Prot
      A4CYJ8, Q7Z601, Q86SL3
      Related
      ENSP00000335158.4, ENST00000335666.4
      Conserved Domains (1) summary
      pfam00001
      Location:176414
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      74367506..74372600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      75258167..75263271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)