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    PAPLA1 Phosphatidic Acid Phospholipase A1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34109, updated on 17-Dec-2024

    Summary

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    Official Symbol
    PAPLA1provided by FlyBase
    Official Full Name
    Phosphatidic Acid Phospholipase A1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031990
    Locus tag
    Dmel_CG8552
    See related
    AllianceGenome:FB:FBgn0031990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14278; CG8552; Dmel\CG8552; DmTGL; PAP; Sec23-IP
    Summary
    Enables phospholipase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; rhodopsin biosynthetic process; and spermatogenesis. Located in COPII-coated ER to Golgi transport vesicle. Is expressed in several structures, including adult brain cell body rind; adult head; germline cell; gland; and gut section. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 54. Orthologous to human DDHD2 (DDHD domain containing 2) and SEC23IP (SEC23 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PAPLA1 in Genome Data Viewer
    Location:
    28E7-28E9; 2-30 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8134247..8159638, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8134247..8159638, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4984 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rabenosyn-5 Neighboring gene Acyl-CoA binding protein 1 Neighboring gene piezo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane attachment and structure models of lipid storage droplet protein 1. Lin P, et al. Biochim Biophys Acta, 2014 Mar. PMID 24333382, Free PMC Article
    2. Lipid Hydrolase Enzymes: Pragmatic Prolongevity Targets for Improved Human Healthspan? Johnson AA. Rejuvenation Res, 2020 Apr. PMID 31426688
    3. Inference of positive and negative selection on the 5' regulatory regions of Drosophila genes. Kohn MH, et al. Mol Biol Evol, 2004 Feb. PMID 14660692
    4. Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila. Gáliková M, et al. Sci Rep, 2017 Apr 19. PMID 28422159, Free PMC Article
    5. Phosphatidic acid phospholipase A1 mediates ER-Golgi transit of a family of G protein-coupled receptors. Kunduri G, et al. J Cell Biol, 2014 Jul 7. PMID 25002678, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this work reveals novel physiological functions of PAPLA1, which are likely evolutionary conserved from flies to humans.
      Title: Spastic paraplegia-linked phospholipase PAPLA1 is necessary for development, reproduction, and energy metabolism in Drosophila.
    2. The Drosophila proteinin CG8552 is a phosphatidic acid phospholipase A1 and mediates endoplasmic reticulum-Golgi transit of a family of G protein-coupled receptors.
      Title: Phosphatidic acid phospholipase A1 mediates ER-Golgi transit of a family of G protein-coupled receptors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm HDA PubMed 

    General protein information

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    Preferred Names
    phosphatidic acid phospholipase A1
    Names
    CG8552-PA
    CG8552-PB
    CG8552-PD
    CG8552-PE
    PAPLA1-PA
    PAPLA1-PB
    PAPLA1-PD
    PAPLA1-PE
    Sec23-interacting protein
    NP_001188714.1
    NP_001188715.1
    NP_001285741.1
    NP_609185.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8134247..8159638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298812.1 → NP_001285741.1  phosphatidic acid phospholipase A1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285741.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDJ3
      Conserved Domains (2) summary
      pfam02825
      Location:1377 → 1446
      WWE; WWE domain
      pfam02862
      Location:1757 → 1980
      DDHD; DDHD domain

    2. NM_135341.1 → NP_609185.1  phosphatidic acid phospholipase A1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609185.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLS7
      Related
      FBpp0079257, FBtr0079641
      Conserved Domains (2) summary
      pfam02825
      Location:1377 → 1446
      WWE; WWE domain
      pfam02862
      Location:1758 → 1981
      DDHD; DDHD domain

    3. NM_001201785.1 → NP_001188714.1  phosphatidic acid phospholipase A1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRD9
      Conserved Domains (2) summary
      pfam02825
      Location:24 → 93
      WWE; WWE domain
      pfam02862
      Location:405 → 628
      DDHD; DDHD domain

    4. NM_001201786.2 → NP_001188715.1  phosphatidic acid phospholipase A1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188715.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRD9
      Conserved Domains (2) summary
      pfam02825
      Location:24 → 93
      WWE; WWE domain
      pfam02862
      Location:405 → 628
      DDHD; DDHD domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRD9 M9MRD9
    Q8MQQ8 Q8MQQ8
    Q9VLS7 Q9VLS7
    X2JDJ3 X2JDJ3

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