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    Sec14l3 SEC14-like lipid binding 3 [ Mus musculus (house mouse) ]

    Gene ID: 380683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec14l3provided by MGI
    Official Full Name
    SEC14-like lipid binding 3provided by MGI
    Primary source
    MGI:MGI:3617848
    See related
    Ensembl:ENSMUSG00000054986 AllianceGenome:MGI:3617848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110069O07Rik
    Summary
    Predicted to be active in cytoplasm. Orthologous to human SEC14L3 (SEC14 like lipid binding 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward lung adult (RPKM 188.4) See more
    Orthologs
    human all
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    Genomic context

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    See Sec14l3 in Genome Data Viewer
    Location:
    11 A1; 11 2.86 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4014853..4028990)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4064853..4078990)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11954 Neighboring gene STARR-seq mESC enhancer starr_28368 Neighboring gene SEC14-like lipid binding 4 Neighboring gene predicted gene, 51935 Neighboring gene STARR-seq mESC enhancer starr_28370 Neighboring gene mitochondrial fission process 1 Neighboring gene SEC14-like lipid binding 2 Neighboring gene predicted gene, 51934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sec14l3 is specifically expressed in mouse airway ciliated cells. Shan L, et al. Inflammation, 2012 Apr. PMID 21796385
    2. Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma. Bartel S, et al. Sci Rep, 2017 Apr 6. PMID 28383034, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli.
      Title: Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma.
    2. study demonstrated that the ciliated cells in the lung selectively express Sec14l3 mRNA; levels of the Sec14l3 mRNA correlated with the differentiation of ciliated cells
      Title: Sec14l3 is specifically expressed in mouse airway ciliated cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SEC14-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029937.2 → NP_001025108.1  SEC14-like protein 3

      See identical proteins and their annotated locations for NP_001025108.1

      Status: VALIDATED

      Source sequence(s)
      AK004424, AK136060, AL807395, BC138982
      Consensus CDS
      CCDS24375.1
      UniProtKB/TrEMBL
      Q5SQ27
      Related
      ENSMUSP00000065084.7, ENSMUST00000068322.7
      Conserved Domains (2) summary
      smart00516
      Location:76 → 246
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4014853..4028990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243730.2 → XP_011242032.1  SEC14-like protein 3 isoform X1

      Conserved Domains (1) summary
      smart00516
      Location:22 → 192
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    Nucleotide Protein Strain
    Heading Accession and Version

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