fhl1b four and a half LIM domains 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fhl1bprovided by ZNC
Official Full Name: four and a half LIM domains 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031219-1
See related: Ensembl:ENSDARG00000056653 AllianceGenome:ZFIN:ZDB-GENE-031219-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fhl; cb1039
Summary: Predicted to enable transmembrane transporter binding activity. Acts upstream of or within several processes, including endocrine pancreas development; liver development; and pancreas regeneration. Is expressed in several structures, including cardiovascular system; digestive system; hypochord; liver primordium; and musculature system. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (26598078..26620943)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (26636365..26659230)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we have uncovered FHL1 as a novel potential regulator of calcium homeostasis in both fish and humans and have implicated it in isolated hypoparathyroidism.
Title: A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism.
these data reveal novel and critical functions of Fhl1b in the hepatic versus pancreatic fate decision and in beta-cell regeneration.
Title: Four and a Half LIM Domains 1b (Fhl1b) Is Essential for Regulating the Liver versus Pancreas Fate Decision and for β-Cell Regeneration.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: four and a half LIM domains protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199217.1 → NP_954687.1 four and a half LIM domains protein 1b

See identical proteins and their annotated locations for NP_954687.1

Status: PROVISIONAL

Source sequence(s)

BC053279

UniProtKB/TrEMBL

Q7T327

Related

ENSDARP00000073643.4, ENSDART00000079187.6

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

26598078..26620943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305310.4 → XP_009303585.1 four and a half LIM domains protein 1b isoform X1

UniProtKB/TrEMBL

A0A8M3AWS1, F1Q7A2

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)