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    MECR mitochondrial trans-2-enoyl-CoA reductase [ Bos taurus (domestic cattle) ]

    Gene ID: 353301, updated on 30-Jan-2025

    Summary

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    Official Symbol
    MECRprovided by VGNC
    Official Full Name
    mitochondrial trans-2-enoyl-CoA reductaseprovided by VGNC
    Primary source
    VGNC:VGNC:31345
    See related
    BGD:BT28760; EnsemblRapid:ENSBTAG00070010663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NRBF1
    Orthologs
    human mouse all
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    Genomic context

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    See MECR in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (124332566..124368422)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343608 Neighboring gene protein tyrosine phosphatase receptor type U Neighboring gene U6 spliceosomal RNA Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II. Miinalainen IJ, et al. J Biol Chem, 2003 May 30. PMID 12654921
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC134158

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables trans-2-enoyl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enoyl-[acyl-carrier-protein] reductase, mitochondrial
    Names
    2-enoyl thioester reductase
    NRBF-1
    btNrbf-1
    nuclear receptor binding factor 1
    trans-2-enoyl-CoA reductase, mitochondrial
    NP_858055.1
    XP_024855125.2
    XP_024855126.2
    XP_059747926.1
    XP_059747927.1
    XP_059747929.1
    XP_059747930.1
    XP_059747931.1
    XP_059747932.1
    XP_059747933.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181669.2 → NP_858055.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_858055.1

      Status: PROVISIONAL

      Source sequence(s)
      AY256973
      UniProtKB/Swiss-Prot
      Q7YS70
      UniProtKB/TrEMBL
      F1MEY2
      Related
      ENSBTAP00070014276.1, ENSBTAT00070024016.1
      Conserved Domains (2) summary
      cd08290
      Location:44 → 373
      ETR; 2-enoyl thioester reductase (ETR)
      COG0604
      Location:44 → 352
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      124332566..124368422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024999357.2 → XP_024855125.2  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0AAA9RUC1
      Related
      ENSBTAP00070014246.1, ENSBTAT00070023977.1

    2. XM_059891946.1 → XP_059747929.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0AAA9RUC1

    3. XM_024999358.2 → XP_024855126.2  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      F1MEY2

    4. XM_059891943.1 → XP_059747926.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

    5. XM_059891944.1 → XP_059747927.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X4

      Related
      ENSBTAP00070014224.1, ENSBTAT00070023949.1

    6. XM_059891950.1 → XP_059747933.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X7

    7. XM_059891948.1 → XP_059747931.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X6

    8. XM_059891947.1 → XP_059747930.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X6

    9. XM_059891949.1 → XP_059747932.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X6

    RNA

    1. XR_003037107.2 RNA Sequence

    2. XR_009496600.1 RNA Sequence

    3. XR_009496601.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YS70.1 GenPept UniProtKB/Swiss-Prot:Q7YS70

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