Apoo apolipoprotein O [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apooprovided by MGI
Official Full Name: apolipoprotein Oprovided by MGI
Primary source: MGI:MGI:1915566
See related: Ensembl:ENSMUSG00000079508 AllianceGenome:MGI:1915566
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Micos26; 0610008C08Rik; 1110019O03Rik
Summary: Predicted to be involved in cristae formation. Located in mitochondrion. Is expressed in adrenal gland; liver left lobe; and liver right lobe. Orthologous to human APOO (apolipoprotein O). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 13.3), kidney adult (RPKM 6.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: X C3; X 41.56 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (93410615..93460699)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (94367010..94417093)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
Title: Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis.
Title: Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis.
Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARalpha-mediated functional interplay between mitochondria and peroxisomes.
Title: Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and peroxisomes.
MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease.
Title: MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease.
The liver function indices (serum ALT and AST) were clearly elevated, and the ultrastructure of cellular mitochondria was distinctly altered in the liver after apoO overexpression. Further, mitochondrial membrane potential decreased with hApoO treatment in L02 cells.
Title: Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function.
APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility.
Title: Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.
Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.
Title: Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.
apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein
Title: ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cristae formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cristae formation	ISO Inferred from Sequence Orthology more info
involved_in cristae formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of MICOS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MICOS complex	ISO Inferred from Sequence Orthology more info
part_of MICOS complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MICOS complex subunit Mic26

Names: MICOS complex subunit Mic23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199337.1 → NP_001186266.1 MICOS complex subunit Mic26 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different segment for its 5' end which utilizes an upstream start codon, compared to variant 1. The resulting protein (isoform 2) is longer when it is compared to isoform 1.

Source sequence(s)

AK002320, DV662362

Consensus CDS

CCDS57769.1

UniProtKB/Swiss-Prot

Q9DCZ4

Related

ENSMUSP00000109530.3, ENSMUST00000113897.9

Conserved Domains (1) summary

pfam09769
Location:55 → 191

ApoO; Apolipoprotein O
NM_001199338.1 → NP_001186267.1 MICOS complex subunit Mic26 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1. Variants 3 and 4 encode the same protein.

Source sequence(s)

AK002320, AK003831, DV662362

Consensus CDS

CCDS57770.1

UniProtKB/TrEMBL

Q3KNM9

Related

ENSMUSP00000109529.2, ENSMUST00000113896.8

Conserved Domains (1) summary

pfam09769
Location:7 → 143

ApoO; Apolipoprotein O
NM_001199339.1 → NP_001186268.1 MICOS complex subunit Mic26 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1. Variants 3 and 4 encode the same protein.

Source sequence(s)

AK002320, BC016557

Consensus CDS

CCDS57770.1

UniProtKB/TrEMBL

Q3KNM9

Related

ENSMUSP00000109528.2, ENSMUST00000113895.2

Conserved Domains (1) summary

pfam09769
Location:7 → 143

ApoO; Apolipoprotein O
NM_026673.4 → NP_080949.2 MICOS complex subunit Mic26 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the more frequently occurring transcript. Variant 1 encodes isoform 1.

Source sequence(s)

BU534555, CB595096, DV662362, EL957008

Consensus CDS

CCDS53136.1

UniProtKB/Swiss-Prot

B1ASQ2, B1ASQ3, Q9D186, Q9DCZ4

UniProtKB/TrEMBL

Q3KNM9

Related

ENSMUSP00000109531.2, ENSMUST00000113898.8

Conserved Domains (1) summary

pfam09769
Location:41 → 177

ApoO; Apolipoprotein O

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

93410615..93460699

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247666.3 → XP_011245968.1 MICOS complex subunit Mic26 isoform X1

Conserved Domains (1) summary

pfam09769
Location:54 → 177

ApoO; Apolipoprotein O
XM_011247668.4 → XP_011245970.1 MICOS complex subunit Mic26 isoform X2

Conserved Domains (1) summary

pfam09769
Location:20 → 143

ApoO; Apolipoprotein O
XM_011247667.4 → XP_011245969.1 MICOS complex subunit Mic26 isoform X2

Conserved Domains (1) summary

pfam09769
Location:20 → 143

ApoO; Apolipoprotein O
XM_011247669.3 → XP_011245971.1 MICOS complex subunit Mic26 isoform X2

Conserved Domains (1) summary

pfam09769
Location:20 → 143

ApoO; Apolipoprotein O