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    PLIN2 perilipin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 280981, updated on 27-Dec-2024

    Summary

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    Official Symbol
    PLIN2provided by VGNC
    Official Full Name
    perilipin 2provided by VGNC
    Primary source
    VGNC:VGNC:33030
    See related
    BGD:BT10600; Ensembl:ENSBTAG00000005718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ADFP
    Orthologs
    human mouse all
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    Genomic context

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    See PLIN2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (25117164..25131174)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 4C Neighboring gene ribosomal protein S6 Neighboring gene cytochrome c oxidase subunit 6B1-like Neighboring gene HAUS augmin like complex subunit 6 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene Ras related GTP binding A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Effect of different culture systems on adipocyte differentiation-related protein (ADRP) in bovine embryos. Al Darwich A, et al. Anim Reprod Sci, 2014 Mar. PMID 24560670
    2. ADFP promoter polymorphism associated with marbling score in Korean cattle. Cheong HS, et al. BMB Rep, 2009 Aug 31. PMID 19712591
    3. Isolation of adipophilin and butyrophilin from bovine milk and characterization of a cDNA encoding adipophilin. Nielsen RL, et al. J Dairy Sci, 1999 Dec. PMID 10629799
    4. Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis. Straub BK, et al. Hepatology, 2008 Jun. PMID 18393390
    5. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate that bovine embryos at the blastocyst stage expressed ADRP mRNA and protein, and that the embryonic culture system modified this expression.
      Title: Effect of different culture systems on adipocyte differentiation-related protein (ADRP) in bovine embryos.
    2. 25 novel polymorphisms were identified within all exons and their flanking regions of ADFP, including the promoter region.
      Title: ADFP promoter polymorphism associated with marbling score in Korean cattle.
    3. Adipophilin and TIP47 are expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes.
      Title: Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC127212

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in lipid storage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of sequestering of triglyceride IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    perilipin-2
    Names
    ADRP
    adipophilin
    adipose differentiation-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173980.2 → NP_776405.1  perilipin-2

      See identical proteins and their annotated locations for NP_776405.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ011680
      UniProtKB/Swiss-Prot
      Q3T0Y0, Q9TUM6
      UniProtKB/TrEMBL
      A1L5C2
      Related
      ENSBTAP00000007519.3, ENSBTAT00000007519.5
      Conserved Domains (1) summary
      pfam03036
      Location:6 → 395
      Perilipin; Perilipin family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25117164..25131174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005209905.4 → XP_005209962.1  perilipin-2 isoform X2

      UniProtKB/TrEMBL
      F1MHI1, Q8HZM7
      Related
      ENSBTAP00000031425.4, ENSBTAT00000031470.6
      Conserved Domains (1) summary
      pfam03036
      Location:7 → 395
      Perilipin; Perilipin family

    2. XM_024995432.2 → XP_024851200.1  perilipin-2 isoform X1

      UniProtKB/TrEMBL
      A1L5C2, F1N1N6
      Conserved Domains (1) summary
      pfam03036
      Location:7 → 395
      Perilipin; Perilipin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TUM6.1 GenPept UniProtKB/Swiss-Prot:Q9TUM6

    Gene LinkOut

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