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    Cbarp calcium channel, voltage-dependent, beta subunit associated regulatory protein [ Mus musculus (house mouse) ]

    Gene ID: 100503659, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cbarpprovided by MGI
    Official Full Name
    calcium channel, voltage-dependent, beta subunit associated regulatory proteinprovided by MGI
    Primary source
    MGI:MGI:1354170
    See related
    Ensembl:ENSMUSG00000035640 AllianceGenome:MGI:1354170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dos; R29144/1; 9630008F14
    Summary
    Enables transmembrane transporter binding activity. Involved in negative regulation of calcium ion-dependent exocytosis and negative regulation of voltage-gated calcium channel activity. Located in plasma membrane and secretory granule. Colocalizes with growth cone. Is expressed in nervous system. Orthologous to human CBARP (CACN subunit beta associated regulatory protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 40.2), frontal lobe adult (RPKM 40.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cbarp in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79966268..79976189, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80130434..80140355, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27262 Neighboring gene STARR-positive B cell enhancer ABC_E900 Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch 2 Neighboring gene STARR-seq mESC enhancer starr_27263 Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene serine/threonine kinase 11 Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene ATP synthase F1 subunit delta Neighboring gene STARR-seq mESC enhancer starr_27268 Neighboring gene STARR-seq mESC enhancer starr_27269 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79621397-79621506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79622453-79622640 Neighboring gene midnolin Neighboring gene STARR-positive B cell enhancer ABC_E2949 Neighboring gene cold inducible RNA binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Gu S, et al. Cell Rep, 2019 Jan 22. PMID 30673609
    2. Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice. Nakao A, et al. Front Behav Neurosci, 2015. PMID 26136667, Free PMC Article
    3. Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties. Knowland D, et al. J Clin Invest, 2020 Nov 2. PMID 33074244, Free PMC Article
    4. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Smith DP, et al. Hum Mol Genet, 1999 Aug. PMID 10400995
    5. Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. Zanivan S, et al. J Proteome Res, 2008 Dec. PMID 19367708

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118572

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent calcium channel beta subunit-associated regulatory protein
    Names
    downstream of Stk11 protein
    protein Dos

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195268.2 → NP_001182197.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 1

      See identical proteins and their annotated locations for NP_001182197.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein. There are no mouse full-length transcripts representing this exon combination; it is predicted based on partial transcript alignments and homology data. This RefSeq is incomplete at the 5' end due to lack full-length transcript support and splice pattern ambiguity in the 5' UTR.
      Source sequence(s)
      AC159999
      Consensus CDS
      CCDS56734.1
      UniProtKB/Swiss-Prot
      E9QP85, Q497H6, Q66L44, Q8CBL1, Q9QZY3
      Related
      ENSMUSP00000101008.2, ENSMUST00000105369.8
      Conserved Domains (1) summary
      pfam01140
      Location:337 → 394
      Gag_MA; Matrix protein (MA), p15

    2. NM_001421397.1 → NP_001408326.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159999

    3. NM_001421398.1 → NP_001408327.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159999

    4. NM_001421399.1 → NP_001408328.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159999

    5. NM_001421400.1 → NP_001408329.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159999

    6. NM_001421401.1 → NP_001408330.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159999

    RNA

    1. NR_036582.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' region and includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK137009, BC100552, BM947270
      Related
      ENSMUST00000147778.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79966268..79976189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512969.3 → XP_006513032.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X1

      See identical proteins and their annotated locations for XP_006513032.1

      UniProtKB/Swiss-Prot
      E9QP85, Q497H6, Q66L44, Q8CBL1, Q9QZY3
      Conserved Domains (1) summary
      pfam01140
      Location:337 → 394
      Gag_MA; Matrix protein (MA), p15

    2. XM_006512970.4 → XP_006513033.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X4

      See identical proteins and their annotated locations for XP_006513033.1

      Conserved Domains (1) summary
      pfam01140
      Location:266 → 323
      Gag_MA; Matrix protein (MA), p15

    3. XM_006512972.4 → XP_006513035.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X4

      See identical proteins and their annotated locations for XP_006513035.1

      Conserved Domains (1) summary
      pfam01140
      Location:266 → 323
      Gag_MA; Matrix protein (MA), p15

    4. XM_006512968.5 → XP_006513031.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X3

      Conserved Domains (1) summary
      pfam01140
      Location:343 → 400
      Gag_MA; Matrix protein (MA), p15

    5. XM_030244790.2 → XP_030100650.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X6

    6. XM_006512976.3 → XP_006513039.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X6

      See identical proteins and their annotated locations for XP_006513039.1

      UniProtKB/Swiss-Prot
      Q66L44
      Conserved Domains (1) summary
      pfam01140
      Location:70 → 127
      Gag_MA; Matrix protein (MA), p15

    7. XM_006512971.5 → XP_006513034.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X4

      See identical proteins and their annotated locations for XP_006513034.1

      Conserved Domains (1) summary
      pfam01140
      Location:266 → 323
      Gag_MA; Matrix protein (MA), p15

    8. XM_030244789.2 → XP_030100649.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X6

    9. XM_006512967.5 → XP_006513030.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X2

      Conserved Domains (1) summary
      pfam01140
      Location:355 → 412
      Gag_MA; Matrix protein (MA), p15

    10. XM_006512973.2 → XP_006513036.2  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X5

      Conserved Domains (1) summary
      pfam10479
      Location:170 → 313
      FSA_C; Fragile site-associated protein C-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015761.2: Suppressed sequence

      Description
      NM_015761.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66L44.4 GenPept UniProtKB/Swiss-Prot:Q66L44

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