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    Ggn gametogenetin [ Mus musculus (house mouse) ]

    Gene ID: 243897, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ggnprovided by MGI
    Official Full Name
    gametogenetinprovided by MGI
    Primary source
    MGI:MGI:2181461
    See related
    Ensembl:ENSMUSG00000031493 AllianceGenome:MGI:2181461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables identical protein binding activity and ubiquitin protein ligase binding activity. Involved in gamete generation. Acts upstream of or within double-strand break repair; embryo implantation; and protein localization. Located in perinuclear region of cytoplasm. Is expressed in brain; early conceptus; eye; gonad; and metanephros. Human ortholog(s) of this gene implicated in spermatogenic failure 69. Orthologous to human GGN (gametogenetin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 126.0) See more
    Orthologs
    human all
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    Genomic context

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    See Ggn in Genome Data Viewer
    Location:
    7 B1; 7 16.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28869635..28873363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29168391..29173938)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RAS guanyl releasing protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E9287 Neighboring gene family with sequence similarity 98, member C Neighboring gene sprouty-related EVH1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E8159 Neighboring gene STARR-positive B cell enhancer ABC_E1337 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Neighboring gene cation channel sperm associated auxiliary subunit gamma 1 Neighboring gene STARR-positive B cell enhancer ABC_E10433 Neighboring gene STARR-positive B cell enhancer ABC_E4913

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice. Guo K, et al. J Cell Mol Med, 2018 Oct. PMID 30055035, Free PMC Article
    2. Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail. Jamsai D, et al. Reproduction, 2008 Jun. PMID 18502891
    3. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Hansson AS, et al. Am J Pathol, 2004 Mar. PMID 14982849, Free PMC Article
    4. Germ-cell specific protein gametogenetin protein 2 (GGN2), expression in the testis, and association with intracellular membrane. Zhao Q, et al. Mol Reprod Dev, 2005 Sep. PMID 15892049
    5. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. Lu B, et al. J Biol Chem, 2003 May 2. PMID 12574169

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data suggest that GGNBP2, likely mediated by its interaction with GGN1, plays a role in DNA double-strand break repair during meiotic progression of spermatocytes.
      Title: Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice.
    2. Results suggest that GGN plays a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos.
      Title: Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102222

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamete generation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein-containing complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear envelope NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gametogenetin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358852.1 → NP_001345781.1  gametogenetin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC164564
      Consensus CDS
      CCDS90196.1
      UniProtKB/Swiss-Prot
      Q5EBP4, Q80WI9, Q80WJ0, Q80WJ1
      Related
      ENSMUSP00000146750.2, ENSMUST00000209019.2
      Conserved Domains (1) summary
      pfam15685
      Location:2 → 672
      GGN; Gametogenetin

    2. NM_182694.2 → NP_874353.2  gametogenetin isoform 1

      See identical proteins and their annotated locations for NP_874353.2

      Status: VALIDATED

      Source sequence(s)
      BC089358
      Consensus CDS
      CCDS52168.1
      UniProtKB/TrEMBL
      G5E8M4
      Related
      ENSMUSP00000096209.3, ENSMUST00000098609.4
      Conserved Domains (1) summary
      pfam15685
      Location:38 → 708
      GGN; Gametogenetin

    3. NM_182696.3 → NP_874355.1  gametogenetin isoform 3

      See identical proteins and their annotated locations for NP_874355.1

      Status: VALIDATED

      Source sequence(s)
      AC164564
      Consensus CDS
      CCDS21067.1
      UniProtKB/Swiss-Prot
      Q80WJ1
      Related
      ENSMUSP00000033886.8, ENSMUST00000033886.8
      Conserved Domains (1) summary
      pfam15685
      Location:2 → 136
      GGN; Gametogenetin

    RNA

    1. NR_154992.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC164564
      Related
      ENSMUST00000208288.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28869635..28873363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539944.5 → XP_006540007.1  gametogenetin isoform X1

      UniProtKB/TrEMBL
      A0A140LI02
      Related
      ENSMUSP00000146620.2, ENSMUST00000208330.2
      Conserved Domains (1) summary
      pfam15685
      Location:15 → 685
      GGN; Gametogenetin

    2. XM_006539946.2 → XP_006540009.1  gametogenetin isoform X2

      Conserved Domains (1) summary
      pfam15685
      Location:1 → 444
      GGN; Gametogenetin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WJ1.2 GenPept UniProtKB/Swiss-Prot:Q80WJ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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