HSPB2 heat shock protein family B (small) member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HSPB2provided by HGNC
Official Full Name: heat shock protein family B (small) member 2provided by HGNC
Primary source: HGNC:HGNC:5247
See related: Ensembl:ENSG00000170276 MIM:602179; AllianceGenome:HGNC:5247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MKBP; HSP27; Hs.78846; LOH11CR1K
Summary: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]
Expression: Biased expression in heart (RPKM 45.3), fat (RPKM 26.7) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (111912734..111914093)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (111922978..111924337)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (111783458..111784817)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP-27 and HSP-70 negatively regulate protective defence responses from macrophages during mycobacterial infection.
Title: HSP-27 and HSP-70 negatively regulate protective defence responses from macrophages during mycobacterial infection.
Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.
Title: Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.
HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury.
Title: HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury.
Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression.
Title: Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression.
Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6.
Title: Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6.
HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.
Title: HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.
HSPB2 appeared to be epigenetically regulated by non-CpGs island methylation and was associated with temozolomide resistance in glioblastomas cell lines.
Title: Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas.
in differentiating myoblasts, nuclear HSPB2 compartments sequester lamin A.
Title: Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.
HSPB2 competes with HSPB8 for binding to BAG3. In contrast, HSPB3 negatively regulates HSPB2 association with BAG3.
Title: An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.
Three of the differentially expressed heat-schock proteins, HSP90A, HSPB1, and HSPB2, are up-regulated in giant cell tumor of bone patients.
Title: Potential role of heat-shock proteins in giant cell tumors.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-17363 (e-PCR)
- UniSTS:71950

GDB:197835 (e-PCR)
- UniSTS:155957

D11S3407 (e-PCR)
- UniSTS:152648

PMC123035P1 (e-PCR)
- UniSTS:270427

STS-S67070 (e-PCR)
- UniSTS:32091

NoName (e-PCR)
- UniSTS:482396

HSPB2_2418 (e-PCR)
- UniSTS:280769

NoName (e-PCR)
- UniSTS:486646

Readthrough HSPB2-C11orf52

Readthrough gene: HSPB2-C11orf52, Included gene: C11orf52

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables enzyme activator activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to unfolded protein	NAS Non-traceable Author Statement more info	PubMed
involved_in somatic muscle development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heat shock protein beta-2

Names: DMPK-binding protein; heat shock 27kDa protein 2; heat shock protein family B member 2; heat-shock protein beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033080.2 RefSeqGene

Range

4999..6358

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001541.4 → NP_001532.1 heat shock protein beta-2

See identical proteins and their annotated locations for NP_001532.1

Status: REVIEWED

Source sequence(s)

AB096250, AI131288, AP000907

Consensus CDS

CCDS8352.1

UniProtKB/Swiss-Prot

Q16082, Q6I9U7

UniProtKB/TrEMBL

A8KAH6

Related

ENSP00000302476.3, ENST00000304298.4

Conserved Domains (1) summary

cl00175
Location:67 → 148

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.