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    Prss33 serine protease 33 [ Mus musculus (house mouse) ]

    Gene ID: 353130, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prss33provided by MGI
    Official Full Name
    serine protease 33provided by MGI
    Primary source
    MGI:MGI:2661234
    See related
    Ensembl:ENSMUSG00000049620 AllianceGenome:MGI:2661234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eos; mT6; tryptase-6
    Summary
    Enables serine-type peptidase activity. Predicted to be involved in protein kinase C signaling and proteolysis. Located in extracellular space. Is expressed in several structures, including brain; musculature; reproductive system; sensory organ; and spleen. Orthologous to human PRSS33 (serine protease 33). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Prss33 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.08 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24052312..24055667, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23833338..23836693, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene microRNA 5125 Neighboring gene STARR-positive B cell enhancer ABC_E11792 Neighboring gene elongin B Neighboring gene serine protease 41 Neighboring gene serine protease 32

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

    Markers

    Clone Names

    • MGC123869, MGC123870, MGC123871

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine protease 33
    Names
    protease, serine 33
    serine protease EOS
    tryptase 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081399.2NP_001074868.2  serine protease 33 precursor

      See identical proteins and their annotated locations for NP_001074868.2

      Status: VALIDATED

      Source sequence(s)
      AC122821, BC103542, BQ893522
      Consensus CDS
      CCDS37476.2
      UniProtKB/Swiss-Prot
      Q3ZB43, Q80WM7
      Related
      ENSMUSP00000059491.7, ENSMUST00000059906.8
      Conserved Domains (2) summary
      smart00020
      Location:33271
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:34272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24052312..24055667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317516.1XP_017173005.1  serine protease 33 isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:98336
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_006524451.3XP_006524514.1  serine protease 33 isoform X2

      See identical proteins and their annotated locations for XP_006524514.1

      UniProtKB/Swiss-Prot
      Q80WM7
      Conserved Domains (1) summary
      cd00190
      Location:16254
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178370.2: Suppressed sequence

      Description
      NM_178370.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.