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    RIMS1 regulating synaptic membrane exocytosis 1 [ Homo sapiens (human) ]

    Gene ID: 22999, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RIMS1provided by HGNC
    Official Full Name
    regulating synaptic membrane exocytosis 1provided by HGNC
    Primary source
    HGNC:HGNC:17282
    See related
    Ensembl:ENSG00000079841 MIM:606629; AllianceGenome:HGNC:17282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIM; RIM1; CORD7; RAB3IP2
    Summary
    The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
    Expression
    Biased expression in brain (RPKM 5.2), testis (RPKM 1.0) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RIMS1 in Genome Data Viewer
    Location:
    6q13
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (71886550..72403145)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (73067717..73580721)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (72596253..73112847)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_94343 Neighboring gene keratin 19 pseudogene 1 Neighboring gene RNA, U4 small nuclear 66, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:72478705-72479904 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:72541212-72542010 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:72542011-72542808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24736 Neighboring gene forkhead box H1 pseudogene Neighboring gene uncharacterized LOC107986611 Neighboring gene MPRA-validated peak5889 silencer Neighboring gene MPRA-validated peak5890 silencer Neighboring gene DNA polymerase delta 1, catalytic subunit pseudogene Neighboring gene HORMA domain containing 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Localization of a gene (CORD7) for a dominant cone-rod dystrophy to chromosome 6q. Kelsell RE, et al. Am J Hum Genet, 1998 Jul. PMID 9634506, Free PMC Article
    2. Molecular analysis of RIM1 in autosomal recessive Retinitis pigmentosa. Barragan I, et al. Ophthalmic Res, 2005 Mar-Apr. PMID 15746564
    3. Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7). Johnson S, et al. Genomics, 2003 Mar. PMID 12659814
    4. Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels. Weiss N, et al. Pflugers Arch, 2011 Apr. PMID 21331761, Free PMC Article
    5. Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release. Gandini MA, et al. J Biol Chem, 2011 May 6. PMID 21402706, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first reported case of bilateral cystoid macular edema in association with the RIM1 mutation. Overall, our findings were more consistent with a phenotype of retinitis pigmentosa.
      Title: Retinitis pigmentosa and bilateral cystoid macular oedema in a patient heterozygous for the RIM1 mutation previously associated with cone-rod dystrophy 7.
    2. The study identified a region on chromosome 6 comprising the genes SMAP1, B3GAT2, and RIMS1 as novel susceptibility locus for pediatric venous thromboembolism.
      Title: Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to pediatric venous thromboembolism.
    3. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47.
      Title: C-terminal splice variants of P/Q-type Ca(2+) channel Ca(V)2.1 α(1) subunits are differentially regulated by Rab3-interacting molecule proteins.
    4. Here, we report that, like Rab3A, RIM and Munc13 are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
      Title: RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.
    5. a novel functional coupling between RIM1 and the L-type Ca(V) channels via the Ca(V)beta auxiliary subunit that contribute to determine insulin secretion.
      Title: Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release.
    6. Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels.
      Title: Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels.
    7. Observational study of genetic testing. (HuGE Navigator)
      Title: Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    10. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-01-24)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2018-01-24)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Common genetic variation and performance on standardized cognitive tests.
    EBI GWAS Catalog
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog
    Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0340, MGC167823, MGC176677

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosomal vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium-ion regulated exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of presynaptic active zone structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane fusion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of dendrite extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of inhibitory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulated exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in presynaptic active zone TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in presynaptic membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulating synaptic membrane exocytosis protein 1
    Names
    RAB3-interacting protein 2
    rab-3-interacting protein 2
    rab3-interacting molecule 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016209.2 RefSeqGene

      Range
      5002..521597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001168407.2 → NP_001161879.1  regulating synaptic membrane exocytosis protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001161879.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and internal differences, compared to isoform 1.
      Source sequence(s)
      AK294868, AK295001, AL035633, AL445256, BC036608
      Consensus CDS
      CCDS55030.1
      UniProtKB/TrEMBL
      B7Z2W4
      Related
      ENSP00000385649.3, ENST00000401910.7
      Conserved Domains (3) summary
      cd04028
      Location:843 → 988
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_001168408.2 → NP_001161880.1  regulating synaptic membrane exocytosis protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001161880.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and internal differences, compared to isoform 1.
      Source sequence(s)
      AK295001, AL035633, BC036608
      Consensus CDS
      CCDS55029.1
      UniProtKB/TrEMBL
      B7Z9Z3
      Related
      ENSP00000428328.1, ENST00000523963.5
      Conserved Domains (3) summary
      cd04028
      Location:648 → 793
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. NM_001168409.2 → NP_001161881.1  regulating synaptic membrane exocytosis protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001161881.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and internal differences, compared to isoform 1.
      Source sequence(s)
      AK295001, AK309185, AL035633, BC036608
      Consensus CDS
      CCDS55032.1
      UniProtKB/TrEMBL
      B7Z1R9
      Related
      ENSP00000411235.2, ENST00000425662.6
      Conserved Domains (3) summary
      cd04028
      Location:591 → 736
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    4. NM_001168410.2 → NP_001161882.1  regulating synaptic membrane exocytosis protein 1 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001161882.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus and internal differences, compared to isoform 1.
      Source sequence(s)
      AK295001, AK296303, AK308658, AK316108, AL035633, BC036608
      Consensus CDS
      CCDS55031.1
      UniProtKB/TrEMBL
      B7Z9Z3
      Related
      ENSP00000428367.1, ENST00000517827.5
      Conserved Domains (3) summary
      cd04028
      Location:657 → 802
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:201 → 327
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:63 → 148
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    5. NM_001168411.2 → NP_001161883.1  regulating synaptic membrane exocytosis protein 1 isoform 6

      See identical proteins and their annotated locations for NP_001161883.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK295001, AK300853, AL035633, BC036608, DB168720
      Consensus CDS
      CCDS55033.1
      UniProtKB/Swiss-Prot
      Q86UR5
      UniProtKB/TrEMBL
      Q3ZCW0
      Related
      ENSP00000402273.2, ENST00000414192.2
      Conserved Domains (1) summary
      cd04028
      Location:50 → 195
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

    6. NM_001350411.1 → NP_001337340.1  regulating synaptic membrane exocytosis protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL034373, AL390056, AL590011

    7. NM_001350412.1 → NP_001337341.1  regulating synaptic membrane exocytosis protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL390056, AL590011
      Conserved Domains (1) summary
      cl27627
      Location:54 → 132
      UPF0004; Uncharacterized protein family UPF0004

    8. NM_001350413.1 → NP_001337342.1  regulating synaptic membrane exocytosis protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL034373, AL390056, AL590011
      Conserved Domains (1) summary
      cl27627
      Location:83 → 159
      UPF0004; Uncharacterized protein family UPF0004

    9. NM_001350414.2 → NP_001337343.1  regulating synaptic membrane exocytosis protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:830 → 975
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    10. NM_001350415.2 → NP_001337344.1  regulating synaptic membrane exocytosis protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:862 → 1007
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:426 → 633
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    11. NM_001350416.2 → NP_001337345.1  regulating synaptic membrane exocytosis protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:845 → 990
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    12. NM_001350417.2 → NP_001337346.1  regulating synaptic membrane exocytosis protein 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:672 → 817
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    13. NM_001350418.2 → NP_001337347.1  regulating synaptic membrane exocytosis protein 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:836 → 981
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    14. NM_001350419.2 → NP_001337348.1  regulating synaptic membrane exocytosis protein 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:596 → 741
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    15. NM_001350420.2 → NP_001337349.1  regulating synaptic membrane exocytosis protein 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:881 → 1026
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    16. NM_001350421.2 → NP_001337350.1  regulating synaptic membrane exocytosis protein 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:796 → 941
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    17. NM_001350422.2 → NP_001337351.1  regulating synaptic membrane exocytosis protein 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (4) summary
      cd04028
      Location:671 → 816
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25751
      Location:396 → 612
      DUF4045; Domain of unknown function (DUF4045)

    18. NM_001350423.2 → NP_001337352.1  regulating synaptic membrane exocytosis protein 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:759 → 904
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28033
      Location:345 → 556
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    19. NM_001350424.2 → NP_001337353.1  regulating synaptic membrane exocytosis protein 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:625 → 770
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    20. NM_001350425.2 → NP_001337354.1  regulating synaptic membrane exocytosis protein 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:829 → 974
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    21. NM_001350426.2 → NP_001337355.1  regulating synaptic membrane exocytosis protein 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (4) summary
      cd04028
      Location:621 → 766
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28033
      Location:345 → 552
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    22. NM_001350427.2 → NP_001337356.1  regulating synaptic membrane exocytosis protein 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:647 → 792
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    23. NM_001350428.2 → NP_001337357.1  regulating synaptic membrane exocytosis protein 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:649 → 794
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    24. NM_001350429.2 → NP_001337358.1  regulating synaptic membrane exocytosis protein 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:769 → 914
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    25. NM_001350430.2 → NP_001337359.1  regulating synaptic membrane exocytosis protein 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (4) summary
      cd04028
      Location:648 → 793
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25751
      Location:373 → 589
      DUF4045; Domain of unknown function (DUF4045)

    26. NM_001350431.2 → NP_001337360.1  regulating synaptic membrane exocytosis protein 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:875 → 1020
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28033
      Location:347 → 637
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    27. NM_001350432.2 → NP_001337361.1  regulating synaptic membrane exocytosis protein 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:617 → 762
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    28. NM_001350433.2 → NP_001337362.1  regulating synaptic membrane exocytosis protein 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:872 → 1017
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:345 → 615
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    29. NM_001350434.2 → NP_001337363.1  regulating synaptic membrane exocytosis protein 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:697 → 842
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    30. NM_001350435.2 → NP_001337364.1  regulating synaptic membrane exocytosis protein 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:826 → 971
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25836
      Location:391 → 569
      Retinal; Retinal protein

    31. NM_001350436.2 → NP_001337365.1  regulating synaptic membrane exocytosis protein 1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:907 → 1052
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    32. NM_001350437.2 → NP_001337366.1  regulating synaptic membrane exocytosis protein 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:824 → 969
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15449
      Location:368 → 579
      Retinal; Retinal protein

    33. NM_001350438.2 → NP_001337367.1  regulating synaptic membrane exocytosis protein 1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (5) summary
      cd04028
      Location:732 → 877
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:347 → 663
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15449
      Location:531 → 682
      Retinal; Retinal protein

    34. NM_001350439.2 → NP_001337368.1  regulating synaptic membrane exocytosis protein 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:820 → 965
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    35. NM_001350440.2 → NP_001337369.1  regulating synaptic membrane exocytosis protein 1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (4) summary
      cd04028
      Location:620 → 765
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28033
      Location:345 → 551
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    36. NM_001350441.2 → NP_001337370.1  regulating synaptic membrane exocytosis protein 1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:819 → 964
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    37. NM_001350442.2 → NP_001337371.1  regulating synaptic membrane exocytosis protein 1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (5) summary
      cd04028
      Location:733 → 878
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:347 → 664
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15449
      Location:532 → 683
      Retinal; Retinal protein

    38. NM_001350443.2 → NP_001337372.1  regulating synaptic membrane exocytosis protein 1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:810 → 955
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    39. NM_001350444.2 → NP_001337373.1  regulating synaptic membrane exocytosis protein 1 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:768 → 913
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28033
      Location:345 → 556
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    40. NM_001350445.2 → NP_001337374.1  regulating synaptic membrane exocytosis protein 1 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (4) summary
      cd04028
      Location:699 → 844
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:345 → 614
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    41. NM_001350446.2 → NP_001337375.1  regulating synaptic membrane exocytosis protein 1 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:905 → 1050
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:347 → 667
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    42. NM_001350447.2 → NP_001337376.1  regulating synaptic membrane exocytosis protein 1 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:792 → 937
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:345 → 580
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    43. NM_001350448.2 → NP_001337377.1  regulating synaptic membrane exocytosis protein 1 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:844 → 989
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    44. NM_001350449.2 → NP_001337378.1  regulating synaptic membrane exocytosis protein 1 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (4) summary
      cd04028
      Location:641 → 786
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25751
      Location:396 → 582
      DUF4045; Domain of unknown function (DUF4045)

    45. NM_001350450.2 → NP_001337379.1  regulating synaptic membrane exocytosis protein 1 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:624 → 769
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    46. NM_001350452.2 → NP_001337381.1  regulating synaptic membrane exocytosis protein 1 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      Conserved Domains (2) summary
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    47. NM_001350454.2 → NP_001337383.1  regulating synaptic membrane exocytosis protein 1 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:813 → 958
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25836
      Location:391 → 565
      Retinal; Retinal protein

    48. NM_001350455.2 → NP_001337384.1  regulating synaptic membrane exocytosis protein 1 isoform 49

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:597 → 742
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    49. NM_001350456.2 → NP_001337385.1  regulating synaptic membrane exocytosis protein 1 isoform 50

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:904 → 1049
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:347 → 666
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    50. NM_001350457.2 → NP_001337386.1  regulating synaptic membrane exocytosis protein 1 isoform 51

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:823 → 968
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    51. NM_001350458.2 → NP_001337387.1  regulating synaptic membrane exocytosis protein 1 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:846 → 991
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    52. NM_001350459.2 → NP_001337388.1  regulating synaptic membrane exocytosis protein 1 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:797 → 942
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    53. NM_001350460.2 → NP_001337389.1  regulating synaptic membrane exocytosis protein 1 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:803 → 948
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:345 → 574
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    54. NM_001350461.2 → NP_001337390.1  regulating synaptic membrane exocytosis protein 1 isoform 55

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:753 → 898
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    55. NM_001350462.2 → NP_001337391.1  regulating synaptic membrane exocytosis protein 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:858 → 1003
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    56. NM_001350463.2 → NP_001337392.1  regulating synaptic membrane exocytosis protein 1 isoform 57

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:738 → 883
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    57. NM_001350464.2 → NP_001337393.1  regulating synaptic membrane exocytosis protein 1 isoform 58

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      E5RGM0
      Related
      ENSP00000359448.4, ENST00000370420.8
      Conserved Domains (3) summary
      cd04028
      Location:739 → 884
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    58. NM_001350465.2 → NP_001337394.1  regulating synaptic membrane exocytosis protein 1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z1R9
      Conserved Domains (3) summary
      cd04028
      Location:567 → 712
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    59. NM_001350466.2 → NP_001337395.1  regulating synaptic membrane exocytosis protein 1 isoform 60

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:740 → 885
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    60. NM_001350467.2 → NP_001337396.1  regulating synaptic membrane exocytosis protein 1 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      E5RGM0
      Conserved Domains (4) summary
      cd04028
      Location:712 → 857
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:264 → 500
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    61. NM_001350468.2 → NP_001337397.1  regulating synaptic membrane exocytosis protein 1 isoform 62

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      E5RGM0
      Related
      ENSP00000389503.2, ENST00000453976.6
      Conserved Domains (4) summary
      cd04028
      Location:687 → 832
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28033
      Location:264 → 475
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    62. NM_001350469.2 → NP_001337398.1  regulating synaptic membrane exocytosis protein 1 isoform 63

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:763 → 908
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    63. NM_001350470.2 → NP_001337399.1  regulating synaptic membrane exocytosis protein 1 isoform 64 precursor

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:659 → 804
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:201 → 327
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:63 → 148
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    64. NM_001350471.2 → NP_001337400.1  regulating synaptic membrane exocytosis protein 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (4) summary
      cd04028
      Location:790 → 935
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:193 → 319
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:55 → 140
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl25836
      Location:368 → 542
      Retinal; Retinal protein

    65. NM_001350472.2 → NP_001337401.1  regulating synaptic membrane exocytosis protein 1 isoform 66 precursor

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:632 → 777
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:201 → 327
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:63 → 148
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    66. NM_001350473.2 → NP_001337402.1  regulating synaptic membrane exocytosis protein 1 isoform 67 precursor

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z9Z3
      Conserved Domains (3) summary
      cd04028
      Location:633 → 778
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:201 → 327
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:63 → 148
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    67. NM_001350474.2 → NP_001337403.1  regulating synaptic membrane exocytosis protein 1 isoform 68 precursor

      Status: REVIEWED

      Source sequence(s)
      AL035633, AL445256, AL590011
      UniProtKB/TrEMBL
      B7Z2W4
      Related
      ENSP00000430359.1, ENST00000517433.5
      Conserved Domains (3) summary
      cd04028
      Location:754 → 899
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:201 → 327
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:63 → 148
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    68. NM_014989.7 → NP_055804.2  regulating synaptic membrane exocytosis protein 1 isoform 1

      See identical proteins and their annotated locations for NP_055804.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL034373, AL035633, AL390056, AL445256, AL590011
      Consensus CDS
      CCDS47449.1
      UniProtKB/Swiss-Prot
      A7MBN6, B7Z2M0, B7Z2Q9, B7Z3S3, B7Z6S2, E7EX08, E9PCB7, E9PCZ1, E9PF48, E9PHF5, E9PHR1, O15048, Q5JY21, Q5JY25, Q5SZK1, Q86UR5, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6
      Related
      ENSP00000428417.1, ENST00000521978.6
      Conserved Domains (6) summary
      cd04028
      Location:1523 → 1668
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:742 → 868
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:604 → 689
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:191 → 284
      DUF601; Protein of unknown function, DUF601
      cl25574
      Location:257 → 536
      TOP2c; TopoisomeraseII
      cl28890
      Location:131 → 186
      FYVE_like_SF; FYVE domain like superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      71886550..72403145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010517.3 → XP_016866006.1  regulating synaptic membrane exocytosis protein 1 isoform X4

    2. XM_047418419.1 → XP_047274375.1  regulating synaptic membrane exocytosis protein 1 isoform X10

    3. XM_017010522.3 → XP_016866011.1  regulating synaptic membrane exocytosis protein 1 isoform X22

      Related
      ENSP00000513179.1, ENST00000697193.1
      Conserved Domains (6) summary
      cd04028
      Location:1370 → 1515
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:742 → 868
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PLN03237
      Location:257 → 536
      PLN03237; DNA topoisomerase 2; Provisional
      cd00992
      Location:604 → 689
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:191 → 284
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:131 → 186
      FYVE_like_SF; FYVE domain like superfamily

    4. XM_017010520.3 → XP_016866009.1  regulating synaptic membrane exocytosis protein 1 isoform X6

    5. XM_017010516.3 → XP_016866005.1  regulating synaptic membrane exocytosis protein 1 isoform X2

    6. XM_017010519.3 → XP_016866008.1  regulating synaptic membrane exocytosis protein 1 isoform X21

    7. XM_017010521.3 → XP_016866010.1  regulating synaptic membrane exocytosis protein 1 isoform X7

    8. XM_017010525.3 → XP_016866014.1  regulating synaptic membrane exocytosis protein 1 isoform X24

    9. XM_024446369.2 → XP_024302137.1  regulating synaptic membrane exocytosis protein 1 isoform X1

      Conserved Domains (7) summary
      cd04028
      Location:1481 → 1626
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:742 → 868
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:604 → 689
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:191 → 284
      DUF601; Protein of unknown function, DUF601
      cl25574
      Location:257 → 536
      TOP2c; TopoisomeraseII
      cl28033
      Location:873 → 1189
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
      cl28890
      Location:131 → 186
      FYVE_like_SF; FYVE domain like superfamily

    10. XM_017010518.3 → XP_016866007.1  regulating synaptic membrane exocytosis protein 1 isoform X5

    11. XM_011535604.4 → XP_011533906.2  regulating synaptic membrane exocytosis protein 1 isoform X23

    12. XM_047418421.1 → XP_047274377.1  regulating synaptic membrane exocytosis protein 1 isoform X25

      Related
      ENSP00000429959.1, ENST00000517960.5

    13. XM_047418416.1 → XP_047274372.1  regulating synaptic membrane exocytosis protein 1 isoform X3

    14. XM_047418417.1 → XP_047274373.1  regulating synaptic membrane exocytosis protein 1 isoform X8

    15. XM_047418418.1 → XP_047274374.1  regulating synaptic membrane exocytosis protein 1 isoform X9

    16. XM_047418423.1 → XP_047274379.1  regulating synaptic membrane exocytosis protein 1 isoform X13

    17. XM_047418420.1 → XP_047274376.1  regulating synaptic membrane exocytosis protein 1 isoform X11

    18. XM_047418424.1 → XP_047274380.1  regulating synaptic membrane exocytosis protein 1 isoform X14

    19. XM_047418426.1 → XP_047274382.1  regulating synaptic membrane exocytosis protein 1 isoform X16

      Related
      ENSP00000430502.1, ENST00000520567.5

    20. XM_047418422.1 → XP_047274378.1  regulating synaptic membrane exocytosis protein 1 isoform X12

    21. XM_047418425.1 → XP_047274381.1  regulating synaptic membrane exocytosis protein 1 isoform X15

    22. XM_017010537.3 → XP_016866026.1  regulating synaptic membrane exocytosis protein 1 isoform X17

      UniProtKB/TrEMBL
      B7Z2W4

    23. XM_017010546.3 → XP_016866035.1  regulating synaptic membrane exocytosis protein 1 isoform X20

      UniProtKB/TrEMBL
      B7Z2W4

    24. XM_024446372.2 → XP_024302140.1  regulating synaptic membrane exocytosis protein 1 isoform X18

      UniProtKB/TrEMBL
      B7Z2W4
      Conserved Domains (3) summary
      cd04028
      Location:870 → 1015
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:216 → 342
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:78 → 163
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    25. XM_017010544.3 → XP_016866033.1  regulating synaptic membrane exocytosis protein 1 isoform X19

      UniProtKB/TrEMBL
      B7Z2W4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      73067717..73580721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354732.1 → XP_054210707.1  regulating synaptic membrane exocytosis protein 1 isoform X4

    2. XM_054354738.1 → XP_054210713.1  regulating synaptic membrane exocytosis protein 1 isoform X10

    3. XM_054354734.1 → XP_054210709.1  regulating synaptic membrane exocytosis protein 1 isoform X6

    4. XM_054354730.1 → XP_054210705.1  regulating synaptic membrane exocytosis protein 1 isoform X2

    5. XM_054354735.1 → XP_054210710.1  regulating synaptic membrane exocytosis protein 1 isoform X7

    6. XM_054354729.1 → XP_054210704.1  regulating synaptic membrane exocytosis protein 1 isoform X1

    7. XM_054354733.1 → XP_054210708.1  regulating synaptic membrane exocytosis protein 1 isoform X5

    8. XM_054354731.1 → XP_054210706.1  regulating synaptic membrane exocytosis protein 1 isoform X3

    9. XM_054354736.1 → XP_054210711.1  regulating synaptic membrane exocytosis protein 1 isoform X8

    10. XM_054354737.1 → XP_054210712.1  regulating synaptic membrane exocytosis protein 1 isoform X9

    11. XM_054354742.1 → XP_054210717.1  regulating synaptic membrane exocytosis protein 1 isoform X13

    12. XM_054354740.1 → XP_054210715.1  regulating synaptic membrane exocytosis protein 1 isoform X26

    13. XM_054354743.1 → XP_054210718.1  regulating synaptic membrane exocytosis protein 1 isoform X27

    14. XM_054354746.1 → XP_054210721.1  regulating synaptic membrane exocytosis protein 1 isoform X28

    15. XM_054354739.1 → XP_054210714.1  regulating synaptic membrane exocytosis protein 1 isoform X11

    16. XM_054354744.1 → XP_054210719.1  regulating synaptic membrane exocytosis protein 1 isoform X14

    17. XM_054354747.1 → XP_054210722.1  regulating synaptic membrane exocytosis protein 1 isoform X16

    18. XM_054354741.1 → XP_054210716.1  regulating synaptic membrane exocytosis protein 1 isoform X12

    19. XM_054354745.1 → XP_054210720.1  regulating synaptic membrane exocytosis protein 1 isoform X15

    20. XM_054354748.1 → XP_054210723.1  regulating synaptic membrane exocytosis protein 1 isoform X17

    21. XM_054354751.1 → XP_054210726.1  regulating synaptic membrane exocytosis protein 1 isoform X20

    22. XM_054354749.1 → XP_054210724.1  regulating synaptic membrane exocytosis protein 1 isoform X18

    23. XM_054354750.1 → XP_054210725.1  regulating synaptic membrane exocytosis protein 1 isoform X19

    24. XM_054354753.1 → XP_054210728.1  regulating synaptic membrane exocytosis protein 1 isoform X30

    25. XM_054354752.1 → XP_054210727.1  regulating synaptic membrane exocytosis protein 1 isoform X29

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UR5.1 GenPept UniProtKB/Swiss-Prot:Q86UR5

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