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    Oaz2 ornithine decarboxylase antizyme 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501454, updated on 9-Dec-2024

    Summary

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    Symbol
    Oaz2provided by RGD
    Full Name
    ornithine decarboxylase antizyme 2provided by RGD
    Primary source
    RGD:1562933
    See related
    EnsemblRapid:ENSRNOG00000015953 AllianceGenome:RGD:1562933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562933
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in Muscle (RPKM 830.8), Heart (RPKM 637.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Oaz2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75094817..75108634)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66199694..66213513)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71216011..71229788)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene RNA binding protein, mRNA processing factor 2 Neighboring gene uncharacterized LOC103693122 Neighboring gene zinc finger protein 609 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene U6 spliceosomal RNA Neighboring gene PCNA clamp associated factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The antizyme family: polyamines and beyond. Mangold U. IUBMB Life, 2005 Oct. PMID 16223706
    2. Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Olsen RR, et al. Mol Cancer Res, 2011 Oct. PMID 21849468, Free PMC Article
    3. Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells. López-Contreras AJ, et al. J Biol Chem, 2008 Jul 25. PMID 18508777, Free PMC Article
    4. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. Kanerva K, et al. Biochem J, 2008 Jan 1. PMID 17900240
    5. Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. López-Contreras AJ, et al. J Biol Chem, 2006 Oct 13. PMID 16916800

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine decarboxylase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of polyamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ornithine decarboxylase antizyme 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109899.2 → NP_001103369.1  ornithine decarboxylase antizyme 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BQ195681, FQ134463, FQ211793
      UniProtKB/TrEMBL
      A0A8I6A353
      Related
      ENSRNOP00000087417.1, ENSRNOT00000099651.2
      Conserved Domains (1) summary
      pfam02100
      Location:100 → 181
      ODC_AZ; Ornithine decarboxylase antizyme

    2. NM_001301297.1 → NP_001288226.1  ornithine decarboxylase antizyme 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
      Source sequence(s)
      BQ195681, FQ134463, FQ211793
      UniProtKB/TrEMBL
      A0A8I6A353, F1M7B5
      Conserved Domains (1) summary
      pfam02100
      Location:97 → 180
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75094817..75108634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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