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    Ldha lactate dehydrogenase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24533, updated on 9-Dec-2024

    Summary

    Symbol
    Ldhaprovided by RGD
    Full Name
    lactate dehydrogenase Aprovided by RGD
    Primary source
    RGD:2996
    See related
    EnsemblRapid:ENSRNOG00000013009 AllianceGenome:RGD:2996
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CDK1; Ldh1
    Summary
    Enables several functions, including L-lactate dehydrogenase activity; NAD binding activity; and identical protein binding activity. Involved in several processes, including response to cAMP; response to estrogen; and response to hydrogen peroxide. Predicted to be located in sperm fibrous sheath. Predicted to be part of oxidoreductase complex. Predicted to be active in cytosol and mitochondrion. Biomarker of hyperglycemia and hypertension. Orthologous to human LDHA (lactate dehydrogenase A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 10393.8), Liver (RPKM 4796.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ldha in Genome Data Viewer
    Location:
    1q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (106508092..106517512)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (97371823..97381247)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102900288..102909713)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene uncharacterized LOC134483108 Neighboring gene general transcription factor IIH subunit 1 Neighboring gene uncharacterized LOC102552634 Neighboring gene uncharacterized LOC120099812 Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility 101

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-lactate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lactate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in NAD metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glucose catabolic process to lactate via pyruvate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lactate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lactate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pyruvate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of oxidoreductase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    L-lactate dehydrogenase A chain
    Names
    LDH muscle subunit
    LDH-A
    LDH-M
    NP_058721.1
    XP_006229294.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017025.2NP_058721.1  L-lactate dehydrogenase A chain

      See identical proteins and their annotated locations for NP_058721.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P04642
      UniProtKB/TrEMBL
      A0A8I6AMT0, B5DEN4
      Related
      ENSRNOP00000083496.2, ENSRNOT00000102543.2
      Conserved Domains (1) summary
      cd05293
      Location:19329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      106508092..106517512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229232.5XP_006229294.1  L-lactate dehydrogenase A chain isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX39, A0A8I6AMT0
      Related
      ENSRNOP00000017468.2, ENSRNOT00000017468.4
      Conserved Domains (2) summary
      cd05293
      Location:48358
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:54353
      L-LDH-NAD; L-lactate dehydrogenase