Wnk1 WNK lysine deficient protein kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnk1provided by MGI
Official Full Name: WNK lysine deficient protein kinase 1provided by MGI
Primary source: MGI:MGI:2442092
See related: Ensembl:ENSMUSG00000045962 AllianceGenome:MGI:2442092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hsn2; Prkwnk1; EG406236; mKIAA0344; 6430573H23Rik
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular chloride ion homeostasis; and lymphocyte migration into lymph node. Acts upstream of or within several processes, including negative regulation of GTPase activity; negative regulation of pancreatic juice secretion; and protein phosphorylation. Part of protein-containing complex. Is active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 40.9), thymus adult (RPKM 32.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 56.86 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (119900930..120015659, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (119923969..120038695, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma.
Title: WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma.
Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance.
Title: Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance.
KS-WNK1 is required for the renal response to extreme changes in potassium intake.
Title: KS-WNK1 is required for the renal response to extreme changes in potassium intake.
CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1.
Title: CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1.
WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release.
Title: WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release.
B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.
Title: B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.
WNK1 in the kidney.
Title: WNK1 in the kidney.
WNK1 collaborates with TGF-beta in endothelial cell junction turnover and angiogenesis.
Title: WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis.
Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1.
Title: Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1.
L-WNK1 is required for BK channel activation in intercalated cells.
Title: L-WNK1 is required for BK channel activation in intercalated cells.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (2) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235542

PMC283554P1 (e-PCR)
- UniSTS:272408

G67049 (e-PCR)
- UniSTS:178258

Wnk1 (e-PCR), detects polymorphism
- UniSTS:527607

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular hyperosmotic response	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in chemokine (C-C motif) ligand 21 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular chloride ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte migration into lymph node	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membraneless organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in membraneless organelle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell-cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of pancreatic juice secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of termination of RNA polymerase II transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of termination of RNA polymerase II transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of regulation of monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membraneless organelle	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membraneless organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase WNK1

Names: protein kinase lysine-deficient 1; protein kinase with no lysine 1

NP_001171949.1

EC 2.7.11.1

NP_001171950.1

EC 2.7.11.1

NP_001186012.1

EC 2.7.11.1

NP_001186013.1

EC 2.7.11.1

NP_941992.2

EC 2.7.11.1

XP_011239622.1

EC 2.7.11.1

XP_017177031.1

EC 2.7.11.1

XP_017177038.1

EC 2.7.11.1

XP_017177039.1

EC 2.7.11.1

XP_017177041.1

EC 2.7.11.1

XP_017177043.1

EC 2.7.11.1

XP_017177044.1

EC 2.7.11.1

XP_017177045.1

EC 2.7.11.1

XP_017177046.1

EC 2.7.11.1

XP_030111215.1

EC 2.7.11.1

XP_036021959.1

EC 2.7.11.1

XP_036021960.1

EC 2.7.11.1

XP_036021961.1

EC 2.7.11.1

XP_036021962.1

EC 2.7.11.1

XP_036021963.1

EC 2.7.11.1

XP_036021964.1

EC 2.7.11.1

XP_036021965.1

EC 2.7.11.1

XP_036021966.1

EC 2.7.11.1

XP_036021967.1

EC 2.7.11.1

XP_036021968.1

EC 2.7.11.1

XP_036021969.1

EC 2.7.11.1

XP_036021970.1

EC 2.7.11.1

XP_036021971.1

EC 2.7.11.1

XP_036021972.1

EC 2.7.11.1

XP_036021973.1

EC 2.7.11.1

XP_036021974.1

EC 2.7.11.1

XP_036021975.1

EC 2.7.11.1

XP_036021976.1

EC 2.7.11.1

XP_036021977.1

EC 2.7.11.1

XP_036021978.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001185020.1 → NP_001171949.1 serine/threonine-protein kinase WNK1 isoform 2

See identical proteins and their annotated locations for NP_001171949.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 5.

Source sequence(s)

AK133738, BC056761, BC138445

Consensus CDS

CCDS85147.1

UniProtKB/TrEMBL

Q6SLK2

Related

ENSMUSP00000145304.2, ENSMUST00000203030.3

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam09770
Location:677 → 812

PAT1; Topoisomerase II-associated protein PAT1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001185021.1 → NP_001171950.1 serine/threonine-protein kinase WNK1 isoform 3

See identical proteins and their annotated locations for NP_001171950.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 5.

Source sequence(s)

AK133738, BC056761, BC145282

Consensus CDS

CCDS51888.1

UniProtKB/TrEMBL

Q6SLK2

Related

ENSMUSP00000086019.6, ENSMUST00000088646.12

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001199083.1 → NP_001186012.1 serine/threonine-protein kinase WNK1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 5. This variant represents the exon combination of the brain and spinal cord variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 4, which is shorter than isoform 5 but has the same N- and C-termini.

Source sequence(s)

AC113092, AK133738, BC054836, BC171955, CN693598

Consensus CDS

CCDS57445.1

UniProtKB/TrEMBL

Q6SLK2

Related

ENSMUSP00000136777.2, ENSMUST00000177761.8

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_001199084.1 → NP_001186013.1 serine/threonine-protein kinase WNK1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5). This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant described in Figure 2F of PubMed ID 18521183.

Source sequence(s)

AC113092, AK133738, BC054836, BC145282, BC171955, CN693598

Consensus CDS

CCDS57444.1

UniProtKB/TrEMBL

Q6SLK2

Related

ENSMUSP00000086017.7, ENSMUST00000088644.13

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
NM_198703.3 → NP_941992.2 serine/threonine-protein kinase WNK1 isoform 1

See identical proteins and their annotated locations for NP_941992.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 5.

Source sequence(s)

AK133738, AY309076, BC056761, BC171955

Consensus CDS

CCDS20478.1

UniProtKB/Swiss-Prot

A6H6V1, B2RRJ7, B7ZNJ4, P83741, Q3UZP3, Q6A083, Q6IFS6, Q6VYA0

UniProtKB/TrEMBL

Q6SLK2

Related

ENSMUSP00000063001.7, ENSMUST00000060043.13

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

119900930..120015659 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166066.1 → XP_036021959.1 serine/threonine-protein kinase WNK1 isoform X1

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1152 → 1564

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166085.1 → XP_036021978.1 serine/threonine-protein kinase WNK1 isoform X30

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1066 → 1478

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_017321556.1 → XP_017177045.1 serine/threonine-protein kinase WNK1 isoform X28

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_030255355.1 → XP_030111215.1 serine/threonine-protein kinase WNK1 isoform X25

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166084.1 → XP_036021977.1 serine/threonine-protein kinase WNK1 isoform X23

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (3) summary

PRK14949
Location:587 → 957

PRK14949; DNA polymerase III subunits gamma and tau; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_011241320.2 → XP_011239622.1 serine/threonine-protein kinase WNK1 isoform X20

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:646 → 1092

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_017321557.1 → XP_017177046.1 serine/threonine-protein kinase WNK1 isoform X29

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam09770
Location:677 → 812

PAT1; Topoisomerase II-associated protein PAT1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_017321555.1 → XP_017177044.1 serine/threonine-protein kinase WNK1 isoform X27

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam09770
Location:677 → 812

PAT1; Topoisomerase II-associated protein PAT1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_017321554.1 → XP_017177043.1 serine/threonine-protein kinase WNK1 isoform X26

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_017321552.1 → XP_017177041.1 serine/threonine-protein kinase WNK1 isoform X24

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_017321550.1 → XP_017177039.1 serine/threonine-protein kinase WNK1 isoform X22

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_017321549.1 → XP_017177038.1 serine/threonine-protein kinase WNK1 isoform X21

UniProtKB/Swiss-Prot

A6H6V1, B2RRJ7, B7ZNJ4, P83741, Q3UZP3, Q6A083, Q6IFS6, Q6VYA0

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_017321542.3 → XP_017177031.1 serine/threonine-protein kinase WNK1 isoform X19

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166082.1 → XP_036021975.1 serine/threonine-protein kinase WNK1 isoform X17

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166079.1 → XP_036021972.1 serine/threonine-protein kinase WNK1 isoform X14

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166076.1 → XP_036021969.1 serine/threonine-protein kinase WNK1 isoform X11

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1066 → 1478

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166081.1 → XP_036021974.1 serine/threonine-protein kinase WNK1 isoform X16

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166067.1 → XP_036021960.1 serine/threonine-protein kinase WNK1 isoform X2

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1152 → 1563

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166083.1 → XP_036021976.1 serine/threonine-protein kinase WNK1 isoform X18

UniProtKB/TrEMBL

Q6SLK2

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166080.1 → XP_036021973.1 serine/threonine-protein kinase WNK1 isoform X15

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166078.1 → XP_036021971.1 serine/threonine-protein kinase WNK1 isoform X13

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166077.1 → XP_036021970.1 serine/threonine-protein kinase WNK1 isoform X12

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166075.1 → XP_036021968.1 serine/threonine-protein kinase WNK1 isoform X10

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166071.1 → XP_036021964.1 serine/threonine-protein kinase WNK1 isoform X6

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1152 → 1564

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166074.1 → XP_036021967.1 serine/threonine-protein kinase WNK1 isoform X9

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166073.1 → XP_036021966.1 serine/threonine-protein kinase WNK1 isoform X8

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166072.1 → XP_036021965.1 serine/threonine-protein kinase WNK1 isoform X7

Conserved Domains (2) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166070.1 → XP_036021963.1 serine/threonine-protein kinase WNK1 isoform X5

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1152 → 1564

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166068.1 → XP_036021961.1 serine/threonine-protein kinase WNK1 isoform X3

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1152 → 1564

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_036166069.1 → XP_036021962.1 serine/threonine-protein kinase WNK1 isoform X4

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1152 → 1564

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001037155.1: Suppressed sequence

Description

NM_001037155.1: This RefSeq was permanently suppressed because it represents a nervous system-specific exon of WNK1, GeneID 232341, but there currently is insufficient support for a transcript containing this exon.