cpne2 copine II [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpne2provided by ZNC
Official Full Name: copine IIprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7896
See related: Ensembl:ENSDARG00000007753 AllianceGenome:ZFIN:ZDB-GENE-030131-7896
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj39e04; wu:fj39e04; si:ch211-122c9.1
Summary: Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be active in plasma membrane. Orthologous to human CPNE2 (copine 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (17660373..17703462)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (17671082..17714396)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: copine-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045075.2 → NP_001038540.1 copine-2

Status: PROVISIONAL

Source sequence(s)

BX470074, BX470170

UniProtKB/TrEMBL

A0A8N7UYA4, Q1LX40

Related

ENSDARP00000002576.8, ENSDART00000021213.9

Conserved Domains (3) summary

cd04047
Location:171 → 283

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:40 → 157

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:294 → 545

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

17660373..17703462

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159116.5 → XP_005159173.1 copine-2 isoform X1

UniProtKB/TrEMBL

A0A2R8Q0R6, A0A8M2B629

Related

ENSDARP00000146042.1, ENSDART00000186279.1

Conserved Domains (3) summary

cd04047
Location:153 → 265

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:22 → 139

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:276 → 527

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...