slc40a1 solute carrier family 40 member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc40a1provided by ZNC
Official Full Name: solute carrier family 40 member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-000511-8
See related: Ensembl:ENSDARG00000000241 AllianceGenome:ZFIN:ZDB-GENE-000511-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: weh; FPN1; slc39a1
Summary: Enables iron ion transmembrane transporter activity. Acts upstream of or within several processes, including hemoglobin biosynthetic process; hemopoiesis; and response to copper ion. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in digestive system; gill; nervous system; solid lens vesicle; and yolk syncytial layer. Used to study iron deficiency anemia. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (41103150..41113878)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (41301363..41312091)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional impact of mammalian ferroportin mutations studied in zebrafish.
Title: Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables iron ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables iron ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables iron ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemoglobin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within iron ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleate erythrocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to copper ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to iron ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 40 member 1

Names: ferroportin-1; ferroportin1; iron-regulated transporter; solute carrier family 39 (iron-regulated transporter), member 1; solute carrier family 40 (iron-regulated transporter), member 1; weissherbst

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.