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    Gpr68 G protein-coupled receptor 68 [ Mus musculus (house mouse) ]

    Gene ID: 238377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr68provided by MGI
    Official Full Name
    G protein-coupled receptor 68provided by MGI
    Primary source
    MGI:MGI:2441763
    See related
    Ensembl:ENSMUSG00000047415 AllianceGenome:MGI:2441763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ogr1
    Summary
    Predicted to enable G protein-coupled receptor activity. Acts upstream of or within cellular response to pH; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of myeloid leukocyte differentiation. Predicted to be located in plasma membrane. Is expressed in cerebral cortex; early conceptus; primary oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 5.7), thymus adult (RPKM 5.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr68 in Genome Data Viewer
    Location:
    12 E; 12 51.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100842941..100874457, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100876679..100908198, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33064 Neighboring gene predicted gene, 40558 Neighboring gene predicted gene, 25801 Neighboring gene D-glutamate cyclase Neighboring gene STARR-seq mESC enhancer starr_33068 Neighboring gene STARR-positive B cell enhancer ABC_E8500 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene predicted gene, 36572 Neighboring gene coiled-coil domain containing 88C Neighboring gene RIKEN cDNA A630072L19 gene Neighboring gene STARR-positive B cell enhancer ABC_E8501 Neighboring gene STARR-positive B cell enhancer ABC_E7169 Neighboring gene predicted gene, 36756 Neighboring gene STARR-seq mESC enhancer starr_33081

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior. Xu Y, et al. Mol Brain, 2020 Sep 29. PMID 32993733, Free PMC Article
    2. Increased bone density in mice lacking the proton receptor OGR1. Krieger NS, et al. Kidney Int, 2016 Mar. PMID 26880453, Free PMC Article
    3. Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets. Horman SR, et al. Oncotarget, 2017 Nov 21. PMID 29245949, Free PMC Article
    4. Real-time monitoring of pH-dependent intracellular trafficking of ovarian cancer G protein-coupled receptor 1 in living leukocytes. Tan M, et al. J Biosci Bioeng, 2018 Sep. PMID 29655915
    5. OGR1/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages. D'Souza CA, et al. PLoS One, 2016. PMID 26828924, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A.
      Title: pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A.
    2. GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
      Title: GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
    3. The orphan receptor GPR68 is expressed in the hypothalamus and is involved in the regulation of feeding.
      Title: The orphan receptor GPR68 is expressed in the hypothalamus and is involved in the regulation of feeding.
    4. OGR1-dependent regulation of the allergen-induced asthma phenotype.
      Title: OGR1-dependent regulation of the allergen-induced asthma phenotype.
    5. Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.
      Title: Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.
    6. The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis.
      Title: The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis.
    7. RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain.
      Title: RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain.
    8. GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior.
      Title: GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior.
    9. GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia.
      Title: GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia.
    10. The authors show OGR1 mediated the effects of acidic environment on proliferation, migration, and angiogenesis of endothelial progenitor cells.
      Title: OGR1 mediates the inhibitory effects of acidic environment on proliferation and angiogenesis of endothelial progenitor cells.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of osteoclast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of osteoclast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ovarian cancer G-protein coupled receptor 1
    Names
    sphingosylphosphorylcholine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177673.1 → NP_001171144.1  ovarian cancer G-protein coupled receptor 1

      See identical proteins and their annotated locations for NP_001171144.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC126262, AI604270, AK036659, AK087410
      Consensus CDS
      CCDS26109.1
      UniProtKB/Swiss-Prot
      Q148P7, Q3U1L3, Q80T34, Q8BFQ3
      UniProtKB/TrEMBL
      Q3U3P5
      Related
      ENSMUSP00000105692.2, ENSMUST00000110065.8
      Conserved Domains (2) summary
      pfam00001
      Location:58 → 286
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35 → 156
      7tm_4; Olfactory receptor

    2. NM_001177674.2 → NP_001171145.1  ovarian cancer G-protein coupled receptor 1

      See identical proteins and their annotated locations for NP_001171145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC126262
      Consensus CDS
      CCDS26109.1
      UniProtKB/Swiss-Prot
      Q148P7, Q3U1L3, Q80T34, Q8BFQ3
      UniProtKB/TrEMBL
      Q3U3P5
      Related
      ENSMUSP00000057510.4, ENSMUST00000053668.10
      Conserved Domains (2) summary
      pfam00001
      Location:58 → 286
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35 → 156
      7tm_4; Olfactory receptor

    3. NM_001403314.1 → NP_001390243.1  ovarian cancer G-protein coupled receptor 1

      Status: VALIDATED

      Source sequence(s)
      AC126262
      UniProtKB/Swiss-Prot
      Q148P7, Q3U1L3, Q80T34, Q8BFQ3
      UniProtKB/TrEMBL
      Q3U3P5

    4. NM_175493.4 → NP_780702.1  ovarian cancer G-protein coupled receptor 1

      See identical proteins and their annotated locations for NP_780702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC126262, AI604270, AK036659
      Consensus CDS
      CCDS26109.1
      UniProtKB/Swiss-Prot
      Q148P7, Q3U1L3, Q80T34, Q8BFQ3
      UniProtKB/TrEMBL
      Q3U3P5
      Related
      ENSMUSP00000105693.2, ENSMUST00000110066.8
      Conserved Domains (2) summary
      pfam00001
      Location:58 → 286
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:35 → 156
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      100842941..100874457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFQ3.1 GenPept UniProtKB/Swiss-Prot:Q8BFQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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