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    Pmpcb peptidase, mitochondrial processing subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64198, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pmpcbprovided by RGD
    Official Full Name
    peptidase, mitochondrial processing subunit betaprovided by RGD
    Primary source
    RGD:621297
    See related
    EnsemblRapid:ENSRNOG00000012693 AllianceGenome:RGD:621297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mppb
    Summary
    Enables metalloendopeptidase activity. Contributes to metallopeptidase activity. Involved in protein processing involved in protein targeting to mitochondrion. Part of mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 633.1), Adrenal (RPKM 516.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pmpcb in Genome Data Viewer
    Location:
    4q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14189807..14202584, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13297583..13310363, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (9908838..9921615, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene ADP-ribosylation factor 1, pseudogene 3 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mitochondrial processing peptidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial-processing peptidase subunit beta
    Names
    P-52
    beta-MPP
    mitochondrial processing peptidase beta subunit
    peptidase (mitochondrial processing) beta
    peptidase, mitochondrial processing beta subunit
    NP_071790.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022395.2NP_071790.1  mitochondrial-processing peptidase subunit beta precursor

      See identical proteins and their annotated locations for NP_071790.1

      Status: PROVISIONAL

      Source sequence(s)
      L12965
      UniProtKB/Swiss-Prot
      Q03346, Q68G08
      UniProtKB/TrEMBL
      A6K5A7
      Related
      ENSRNOP00000017017.5, ENSRNOT00000017018.7
      Conserved Domains (3) summary
      COG0612
      Location:46478
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:68215
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:220404
      Peptidase_M16_C; Peptidase M16 inactive domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      14189807..14202584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)