U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Tagln transgelin [ Mus musculus (house mouse) ]

    Gene ID: 21345, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taglnprovided by MGI
    Official Full Name
    transgelinprovided by MGI
    Primary source
    MGI:MGI:106012
    See related
    Ensembl:ENSMUSG00000032085 AllianceGenome:MGI:106012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sm22; Sm22a; Ws310
    Summary
    This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010]
    Expression
    Biased expression in bladder adult (RPKM 3112.1), stomach adult (RPKM 1002.7) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tagln in Genome Data Viewer
    Location:
    9 A5.2; 9 25.36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45840926..45847356, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45929628..45936058, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45655339-45655522 Neighboring gene beta-site APP cleaving enzyme 1 Neighboring gene ring finger protein 214 Neighboring gene predicted gene, 24646 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene RIKEN cDNA A830035O19 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transgelin
    Names
    SM22-alpha
    Sm22alpha
    actin-associated protein p27
    smooth muscle protein 22-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011526.5NP_035656.1  transgelin

      See identical proteins and their annotated locations for NP_035656.1

      Status: REVIEWED

      Source sequence(s)
      AC122273, AK077235
      Consensus CDS
      CCDS23137.1
      UniProtKB/Swiss-Prot
      P37804, Q545W0
      Related
      ENSMUSP00000034590.3, ENSMUST00000034590.4
      Conserved Domains (3) summary
      COG5199
      Location:14189
      SCP1; Calponin [Cytoskeleton]
      cd00014
      Location:25137
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:175198
      Calponin; Calponin family repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45840926..45847356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)