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    Casr calcium-sensing receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24247, updated on 27-Nov-2024

    Summary

    Official Symbol
    Casrprovided by RGD
    Official Full Name
    calcium-sensing receptorprovided by RGD
    Primary source
    RGD:2277
    See related
    EnsemblRapid:ENSRNOG00000002265 AllianceGenome:RGD:2277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PCaR1; RaKCaR
    Summary
    Enables integrin binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; and positive regulation of cell communication. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Is active in presynaptic membrane. Used to study cardiomyopathy. Biomarker of atherosclerosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 159.2) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Casr in Genome Data Viewer
    Location:
    11q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77738398..77813639)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64235251..64304811)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67188204..67262261)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin-like domain containing receptor 1 Neighboring gene CD86 molecule Neighboring gene uncharacterized LOC134481008 Neighboring gene U6 spliceosomal RNA Neighboring gene stefin A3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in bile acid secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hepatocyte growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to low-density lipoprotein particle stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to peptide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chloride transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fat pad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of positive chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fibroblast growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to metal ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    extracellular calcium-sensing receptor
    Names
    Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism)
    parathyroid Cell calcium-sensing receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309638.1NP_001296567.1  extracellular calcium-sensing receptor precursor

      See identical proteins and their annotated locations for NP_001296567.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P48442
      UniProtKB/TrEMBL
      A6IRC6, Q80ZA8
      Conserved Domains (3) summary
      cd15282
      Location:611862
      7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
      cd06364
      Location:33530
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:538591
      NCD3G; Nine Cysteines Domain of family 3 GPCR
    2. NM_016996.2NP_058692.1  extracellular calcium-sensing receptor precursor

      See identical proteins and their annotated locations for NP_058692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P48442
      UniProtKB/TrEMBL
      A6IRC6, Q80ZA8
      Related
      ENSRNOP00000003092.3, ENSRNOT00000003092.7
      Conserved Domains (3) summary
      cd15282
      Location:611862
      7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
      cd06364
      Location:33530
      PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam07562
      Location:538591
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      77738398..77813639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270272.1XP_063126342.1  extracellular calcium-sensing receptor isoform X1

      UniProtKB/Swiss-Prot
      P48442
      UniProtKB/TrEMBL
      A6IRC6
    2. XM_063270273.1XP_063126343.1  extracellular calcium-sensing receptor isoform X1

      UniProtKB/Swiss-Prot
      P48442
      UniProtKB/TrEMBL
      A6IRC6