Igf2 insulin-like growth factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igf2provided by RGD
Official Full Name: insulin-like growth factor 2provided by RGD
Primary source: RGD:2870
See related: EnsemblRapid:ENSRNOG00000020369 AllianceGenome:RGD:2870
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IGFII; RNIGF2
Summary: Predicted to enable protein kinase activator activity and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of blood vessel endothelial cell migration; and positive regulation of vascular endothelial cell proliferation. Located in extracellular space. Used to study osteoporosis. Biomarker of several diseases, including alcoholic neuropathy; brain infarction; congenital diaphragmatic hernia; diabetes mellitus (multiple); and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 612.5), Liver (RPKM 176.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (207243873..207261263, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (197814409..197831802, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (215828102..215839081, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal activity drives IGF2 expression from pericytes to form long-term memory.
Title: Neuronal activity drives IGF2 expression from pericytes to form long-term memory.
The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats.
Title: The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats.
Insulin-like growth factor-2 regulates basal retinal insulin receptor activity.
Title: Insulin-like growth factor-2 regulates basal retinal insulin receptor activity.
Integrin and autocrine IGF2 pathways control fasting insulin secretion in beta-cells.
Title: Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells.
IGF2 expression in inguinal adipose tissues from rats of different ages.
Title: Insulin-like growth factor 2 regulates the proliferation and differentiation of rat adipose-derived stromal cells via IGF-1R and IR.
elevated circulating IGF2 in late pregnancy predominantly stimulates organ growth of the digestive system, and male fetuses are more susceptible toward the IGF2 effects than female fet
Title: IGF2 stimulates fetal growth in a sex- and organ-dependent manner.
DNA methylation changes of rat Nr3c1 and Igf2/H19 during aging that are tissue and sex specific, are reported.
Title: Tissue-, sex-, and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin-like growth factor 2 imprinting control region.
We aimed to investigate whether TSN protected H9c2 cardiomyocytes from AngII-induced activation of IGF-2R pathway (IGF-2 and IGF-2R )and hypertrophy by mediating through Estrogen receptors
Title: Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy.
Post-weaning high-fat (HF) diet intake resulted in the reduction of small follicles in adulthood, whereas maternal HF diet had long-term deleterious consequences on female offspring steroidogenesis and coincided with alteration of the upregulation of the imprinted gene Igf2 and changes in ovarian circadian rhythms.
Title: Detrimental effect of maternal and post-weaning high-fat diet on the reproductive function in the adult female offspring rat: roles of insulin-like growth factor 2 and the ovarian circadian clock.
The results showed that f1 offspring exposed to p,p'-DDE exhibited impaired glucose tolerance, abnormal insulin secretion, beta-cell dysfunction and altered Igf2 and H19 expression induced by Igf2/H19 hypomethylation, which could be transferred to the F3 offspring through the male germ line.
Title: Transgenerational pancreatic impairment with Igf2/H19 epigenetic alteration induced by p,p'-DDE exposure in early life.

Submit: New GeneRIF Correction See all GeneRIFs (48)

General gene information

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Markers

Igf2 (e-PCR), detects polymorphism
- UniSTS:531477

RH94585 (e-PCR)
- UniSTS:119833

D1Mgh22 (e-PCR)
- UniSTS:259390

BE098867 (e-PCR)
- UniSTS:245317

PMC151856P1 (e-PCR)
- UniSTS:271187

D1Wox58 (e-PCR)
- UniSTS:519007

AW742446 (e-PCR)
- UniSTS:208229

Igf2 (e-PCR), detects polymorphism
- UniSTS:143472

Igf2 (e-PCR), detects polymorphism
- UniSTS:143474

Igf2 (e-PCR), detects polymorphism
- UniSTS:143477

Igf2 (e-PCR), detects polymorphism
- UniSTS:143482

D1Mco27 (e-PCR)
- UniSTS:240506

ECD21742 (e-PCR)
- UniSTS:302735

D1Hmgc8 (e-PCR)
- UniSTS:261283

NoName (e-PCR)
- UniSTS:532138

Igf2 (e-PCR), detects polymorphism
- UniSTS:532138

NoName (e-PCR)
- UniSTS:532139

Igf2 (e-PCR), detects polymorphism
- UniSTS:532139

UniSTS:276141 (e-PCR)
- UniSTS:276141

Igf2 (e-PCR), detects polymorphism
- UniSTS:276141

D1Mgh22 (e-PCR)
- UniSTS:239281

D1Arb24 (e-PCR), detects polymorphism
- UniSTS:227006

D1Wox22 (e-PCR)
- UniSTS:119233

Igf2 (e-PCR), detects polymorphism
- UniSTS:516548

RH128370 (e-PCR)
- UniSTS:211678

RH94794 (e-PCR)
- UniSTS:120041

Igf2 (e-PCR), detects polymorphism
- UniSTS:516604

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in embryonic placenta development	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic placenta morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocrine pancreas development	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid hormone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spongiotrophoblast cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor II

Names: IGF-II; Insulin-like growth factor II (somatomedin A); MSA; insulin-like growth factor II (IGF-II); multiplication-stimulating activity; multiplication-stimulating polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190162.1 → NP_001177091.1 insulin-like growth factor II isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001177091.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.

Source sequence(s)

JAXUCZ010000001, X13101

UniProtKB/Swiss-Prot

P01346

UniProtKB/TrEMBL

M9NW49, Q63265

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide
NM_001190163.1 → NP_001177092.1 insulin-like growth factor II isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001177092.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.

Source sequence(s)

JAXUCZ010000001, X14833

UniProtKB/Swiss-Prot

P01346

UniProtKB/TrEMBL

M9NW49, Q63265

Conserved Domains (2) summary

cd04368
Location:28 → 91

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:112 → 166

IGF2_C; Insulin-like growth factor II E-peptide
NM_031511.2 → NP_113699.2 insulin-like growth factor II isoform 1 preproprotein

See identical proteins and their annotated locations for NP_113699.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000001, X14834

UniProtKB/TrEMBL

A6HY76, Q63265

Conserved Domains (2) summary

cd04368
Location:39 → 102

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:123 → 177

IGF2_C; Insulin-like growth factor II E-peptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

207243873..207261263 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096378.2 → XP_038952306.1 insulin-like growth factor II isoform X2

Related

ENSRNOP00000099605.1, ENSRNOT00000164793.1

Conserved Domains (2) summary

cd04368
Location:45 → 108

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...

pfam08365
Location:129 → 183

IGF2_C; Insulin-like growth factor II E-peptide
XM_008760074.4 → XP_008758296.1 insulin-like growth factor II isoform X1

Related

ENSRNOP00000110891.1, ENSRNOT00000172623.1

Conserved Domains (1) summary

cd04368
Location:192 → 255

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...