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    PPP1R12A protein phosphatase 1 regulatory subunit 12A [ Bos taurus (domestic cattle) ]

    Gene ID: 538606, updated on 31-Dec-2024

    Summary

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    Official Symbol
    PPP1R12Aprovided by VGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 12Aprovided by VGNC
    Primary source
    VGNC:VGNC:33223
    See related
    BGD:BT29208; Ensembl:ENSBTAG00000014609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PPP1R12A in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (9309307..9477670, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin 1 Neighboring gene uncharacterized LOC104972334 Neighboring gene small nucleolar RNA SNORA5 Neighboring gene pro-apoptotic WT1 regulator Neighboring gene otogelin like Neighboring gene uncharacterized LOC132345238 Neighboring gene protein tyrosine phosphatase receptor type Q

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148828

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 12A
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 12A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434810.1 → NP_001421739.1  protein phosphatase 1 regulatory subunit 12A

      Status: VALIDATED

      Source sequence(s)
      NKLS02000005
      UniProtKB/TrEMBL
      A0AAA9TLU4

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9309307..9477670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024991984.2 → XP_024847752.1  protein phosphatase 1 regulatory subunit 12A isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LRC7, A0AAA9TLU4
      Related
      ENSBTAP00000062810.2, ENSBTAT00000082646.2
      Conserved Domains (4) summary
      cd00204
      Location:67 → 252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:72 → 103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:873 → 971
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl26073
      Location:52 → 310
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_024991985.2 → XP_024847753.1  protein phosphatase 1 regulatory subunit 12A isoform X5

      UniProtKB/TrEMBL
      A0AAA9TLU4, F1N3L1
      Related
      ENSBTAP00000019454.7, ENSBTAT00000019454.7
      Conserved Domains (4) summary
      cd00204
      Location:67 → 252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:72 → 103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:870 → 968
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl26073
      Location:52 → 310
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_024991983.2 → XP_024847751.1  protein phosphatase 1 regulatory subunit 12A isoform X2

      UniProtKB/TrEMBL
      A0AAA9TLU4, E1BC59
      Related
      ENSBTAP00000053760.4, ENSBTAT00000061600.4
      Conserved Domains (4) summary
      cd00204
      Location:67 → 252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:72 → 103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:929 → 983
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl26073
      Location:52 → 310
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_059886596.1 → XP_059742579.1  protein phosphatase 1 regulatory subunit 12A isoform X3

      UniProtKB/TrEMBL
      A0AAA9TLU4

    RNA

    1. XR_009494419.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001102217.1: Suppressed sequence

      Description
      NM_001102217.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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