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    mfas midline fasciclin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mfasprovided by FlyBase
    Official Full Name
    midline fasciclinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260745
    Locus tag
    Dmel_CG3359
    See related
    AllianceGenome:FB:FBgn0260745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    87A7-9/7; anon-87Af; anon-EST:Liang-97; anon-WO0140519.174; BEST:GH06752; CG3359; clone 97; Dmel\CG3359; FBgn0260745; gh06752; Mfas
    Summary
    Predicted to enable cell adhesion molecule binding activity. Involved in axonogenesis and negative regulation of hemocyte proliferation. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; epithelium; follicle cell; gut section; and midline glial cell. Human ortholog(s) of this gene implicated in congestive heart failure and corneal dystrophy (multiple). Orthologous to several human genes including TGFBI (transforming growth factor beta induced). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mfas in Genome Data Viewer
    Location:
    87A4-87A4; 3-51 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11984862..11993315, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7810584..7819037, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tachykinin Neighboring gene Ectoderm-expressed 3 Neighboring gene Kelch like family member 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Bellosta P, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16087886, Free PMC Article
    2. Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea. Hu S, et al. J Neurobiol, 1998 Apr. PMID 9552168
    3. Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression. Pearson JC, et al. Dev Biol, 2014 Aug 15. PMID 24854999, Free PMC Article
    4. Genomic imprinting absent in Drosophila melanogaster adult females. Coolon JD, et al. Cell Rep, 2012 Jul 26. PMID 22840398, Free PMC Article
    5. The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy. Graca FA, et al. Nat Commun, 2022 May 2. PMID 35501350, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell adhesion molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hemocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    midline fasciclin
    Names
    CG3359-PB
    CG3359-PC
    CG3359-PD
    CG3359-PE
    CG3359-PF
    CG3359-PG
    CG3359-PH
    CG3359-PI
    CG3359-PJ
    CG3359-PK
    CG3359-PL
    CG3359-PM
    CG3359-PN
    CG3359-PO
    CG3359-PP
    CG3359-PQ
    anon-87Af
    mfas-PB
    mfas-PC
    mfas-PD
    mfas-PE
    mfas-PF
    mfas-PG
    mfas-PH
    mfas-PI
    mfas-PJ
    mfas-PK
    mfas-PL
    mfas-PM
    mfas-PN
    mfas-PO
    mfas-PP
    mfas-PQ
    midline fascilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11984862..11993315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176467.1 → NP_788644.1  midline fasciclin, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, Q86B97
      Related
      FBpp0081975, FBtr0082501
      Conserved Domains (2) summary
      smart00554
      Location:249 → 360
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:372 → 502
      Fasciclin; Fasciclin domain

    2. NM_169444.1 → NP_731661.1  midline fasciclin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, Q9VGE9
      Related
      FBpp0081963, FBtr0082489
      Conserved Domains (2) summary
      smart00554
      Location:250 → 361
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:373 → 503
      Fasciclin; Fasciclin domain

    3. NM_176471.1 → NP_788648.1  midline fasciclin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61457, Q9VGF0
      Related
      FBpp0081971, FBtr0082497
      Conserved Domains (2) summary
      smart00554
      Location:315 → 426
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:438 → 568
      Fasciclin; Fasciclin domain

    4. NM_176474.1 → NP_788651.1  midline fasciclin, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, Q86B96
      Related
      FBpp0081976, FBtr0082502
      Conserved Domains (2) summary
      smart00554
      Location:273 → 384
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:396 → 526
      Fasciclin; Fasciclin domain

    5. NM_176476.1 → NP_788653.1  midline fasciclin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, E8NH85, Q86B95
      Related
      FBpp0081969, FBtr0082495
      Conserved Domains (2) summary
      smart00554
      Location:274 → 385
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:397 → 527
      Fasciclin; Fasciclin domain

    6. NM_176478.1 → NP_788655.1  midline fasciclin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH93, Q86B94
      Related
      FBpp0081972, FBtr0082498
      Conserved Domains (2) summary
      smart00554
      Location:339 → 450
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:462 → 592
      Fasciclin; Fasciclin domain

    7. NM_176466.1 → NP_788643.1  midline fasciclin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, Q86B97
      Related
      FBpp0081970, FBtr0082496
      Conserved Domains (2) summary
      smart00554
      Location:249 → 360
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:372 → 502
      Fasciclin; Fasciclin domain

    8. NM_176470.1 → NP_788647.1  midline fasciclin, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788647.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, Q9VGE9
      Related
      FBpp0081965, FBtr0082491
      Conserved Domains (2) summary
      smart00554
      Location:250 → 361
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:373 → 503
      Fasciclin; Fasciclin domain

    9. NM_176472.1 → NP_788649.1  midline fasciclin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61457, Q9VGF0
      Related
      FBpp0081973, FBtr0082499
      Conserved Domains (2) summary
      smart00554
      Location:315 → 426
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:438 → 568
      Fasciclin; Fasciclin domain

    10. NM_176473.1 → NP_788650.1  midline fasciclin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788650.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, Q86B96
      Related
      FBpp0081967, FBtr0082493
      Conserved Domains (2) summary
      smart00554
      Location:273 → 384
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:396 → 526
      Fasciclin; Fasciclin domain

    11. NM_176477.1 → NP_788654.1  midline fasciclin, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, E8NH85, Q86B95
      Related
      FBpp0081974, FBtr0082500
      Conserved Domains (2) summary
      smart00554
      Location:274 → 385
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:397 → 527
      Fasciclin; Fasciclin domain

    12. NM_176469.2 → NP_788646.1  midline fasciclin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, Q9VGE9
      Related
      FBpp0081977
      Conserved Domains (2) summary
      smart00554
      Location:250 → 361
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:373 → 503
      Fasciclin; Fasciclin domain

    13. NM_079600.3 → NP_524324.2  midline fasciclin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524324.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61457, Q9VGF0
      Related
      FBpp0081964
      Conserved Domains (2) summary
      smart00554
      Location:315 → 426
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:438 → 568
      Fasciclin; Fasciclin domain

    14. NM_176468.1 → NP_788645.1  midline fasciclin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, Q9VGE9
      Related
      FBpp0081966, FBtr0082492
      Conserved Domains (2) summary
      smart00554
      Location:250 → 361
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:373 → 503
      Fasciclin; Fasciclin domain

    15. NM_176475.1 → NP_788652.1  midline fasciclin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBY2, E8NH85, Q86B95
      Related
      FBpp0081968, FBtr0082494
      Conserved Domains (2) summary
      smart00554
      Location:274 → 385
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:397 → 527
      Fasciclin; Fasciclin domain

    16. NM_001260137.1 → NP_001247066.1  midline fasciclin, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMM4, E6PBY2
      Conserved Domains (2) summary
      smart00554
      Location:230 → 341
      FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
      pfam02469
      Location:353 → 483
      Fasciclin; Fasciclin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3DMM4 D3DMM4
    O61457 O61457
    Q86B94 Q86B94
    Q86B95 Q86B95
    Q86B96 Q86B96
    Q86B97 Q86B97
    Q9VGE9 Q9VGE9
    Q9VGF0 Q9VGF0

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