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    cib ciboulot [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31359, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cibprovided by FlyBase
    Official Full Name
    ciboulotprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026084
    Locus tag
    Dmel_CG4944
    See related
    AllianceGenome:FB:FBgn0026084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4944; Dmel\CG4944; EG0007-11; EG:EG0007.11
    Summary
    Enables actin monomer binding activity. Involved in brain development and larval central nervous system remodeling. Located in cytosol. Is expressed in several structures, including amnioserosa; ganglia; germline cell; larval muscle cell; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cib in Genome Data Viewer
    Location:
    4A5-4A5; 1-6 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4106113..4110981)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4000146..4005014)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum group A-like Neighboring gene brainiac Neighboring gene NOP2-Sun domain family, member 2 Neighboring gene dim gamma-tubulin 4 Neighboring gene Tat interactive protein 60kDa Neighboring gene twenty-four

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The comparison of beta-thymosin homologues among metazoa supports an arthropod-nematode clade. Manuel M, et al. J Mol Evol, 2000 Oct. PMID 11040289
    2. Central brain postembryonic development in Drosophila: implication of genes expressed at the interhemispheric junction. Boquet I, et al. J Neurobiol, 2000 Jan. PMID 10623899
    3. Integration of proteomic and genetic approaches to assess developmental muscle atrophy. Brooks DS, et al. J Exp Biol, 2021 Nov 1. PMID 34647571, Free PMC Article
    4. The structural basis of actin interaction with multiple WH2/beta-thymosin motif-containing proteins. Aguda AH, et al. Structure, 2006 Mar. PMID 16531231
    5. Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Jodoin JN, et al. Dev Cell, 2015 Dec 21. PMID 26688336, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval central nervous system remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ciboulot
    Names
    CG4944-PA
    CG4944-PB
    CG4944-PC
    CG4944-PD
    CG4944-PE
    beta-thymosin
    cib-PA
    cib-PB
    cib-PC
    cib-PD
    cib-PE
    ciboulet
    ciboulout

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4106113..4110981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297923.1 → NP_001284852.1  ciboulot, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97428
      Conserved Domains (2) summary
      pfam01290
      Location:98 → 129
      Thymosin; Thymosin beta-4 family
      cl27586
      Location:57 → 93
      Thymosin; Thymosin beta-4 family

    2. NM_167001.3 → NP_726908.1  ciboulot, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97428
      Related
      FBpp0070607
      Conserved Domains (2) summary
      pfam01290
      Location:98 → 129
      Thymosin; Thymosin beta-4 family
      cl27586
      Location:57 → 93
      Thymosin; Thymosin beta-4 family

    3. NM_167002.3 → NP_726909.1  ciboulot, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRS7
      Related
      FBpp0070608
      Conserved Domains (2) summary
      smart00152
      Location:57 → 91
      THY; Thymosin beta actin-binding motif
      pfam01290
      Location:10 → 53
      Thymosin; Thymosin beta-4 family

    4. NM_080326.4 → NP_525065.1  ciboulot, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525065.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97428
      Related
      FBpp0070609, FBtr0070641
      Conserved Domains (2) summary
      pfam01290
      Location:98 → 129
      Thymosin; Thymosin beta-4 family
      cl27586
      Location:57 → 93
      Thymosin; Thymosin beta-4 family

    5. NM_001258587.1 → NP_001245516.1  ciboulot, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245516.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97428
      Conserved Domains (2) summary
      pfam01290
      Location:98 → 129
      Thymosin; Thymosin beta-4 family
      cl27586
      Location:57 → 93
      Thymosin; Thymosin beta-4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97428 O97428
    Q8IRS7 Q8IRS7

    Gene LinkOut

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