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    scd stearoyl-CoA desaturase (delta-9-desaturase) [ Danio rerio (zebrafish) ]

    Gene ID: 386661, updated on 22-Dec-2024

    Summary

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    Official Symbol
    scdprovided by ZNC
    Official Full Name
    stearoyl-CoA desaturase (delta-9-desaturase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031106-3
    See related
    Ensembl:ENSDARG00000033662 AllianceGenome:ZFIN:ZDB-GENE-031106-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SCD1
    Summary
    Predicted to enable iron ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Acts upstream of or within fat pad development and swimming behavior. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including female organism; heart; liver; pleuroperitoneal region; and subcutaneous fat. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See scd in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (48390713..48406198)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (48407391..48422876)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member B12b Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene uncharacterized LOC137496859 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. scd knockout activates β-oxidation of fatty acids via accumulating stearic acid (18:0) and induces anorexia in zebrafish. Wu W, et al. Gene, 2023 Jun 30. PMID 37068693
    2. cDNA nucleotide sequence coding for stearoyl-CoA desaturase and its expression in the zebrafish (Danio rerio) embryo. Hsieh SL, et al. Mol Reprod Dev, 2003 Dec. PMID 14579408
    3. Ancient and modern duplication events and the evolution of stearoyl-CoA desaturases in teleost fishes. Evans H, et al. Physiol Genomics, 2008 Sep 17. PMID 18593860, Free PMC Article
    4. Assessment of stromal SCD-induced drug resistance of PDAC using 3D-printed zPDX model chips. Wu C, et al. iScience, 2023 Jan 20. PMID 36590169, Free PMC Article
    5. Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Harjula SE, et al. Dev Comp Immunol, 2020 Feb. PMID 31626817

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. scd knockout activates beta-oxidation of fatty acids via accumulating stearic acid (18:0) and induces anorexia in zebrafish.
      Title: scd knockout activates β-oxidation of fatty acids via accumulating stearic acid (18:0) and induces anorexia in zebrafish.
    2. Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy.
      Title: Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy.
    3. whole-mount in situ hybridization and real-time quantitative RT-PCR to identify expression of the zebrafish SCD gene at five different stages of development
      Title: cDNA nucleotide sequence coding for stearoyl-CoA desaturase and its expression in the zebrafish (Danio rerio) embryo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fat pad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monounsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within swimming behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA desaturase
    NP_942110.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198815.2 → NP_942110.2  acyl-CoA desaturase

      Status: VALIDATED

      Source sequence(s)
      FP102054
      UniProtKB/TrEMBL
      A0A8M1P985, F1QG70
      Related
      ENSDARP00000124185.1, ENSDART00000149351.2
      Conserved Domains (2) summary
      cd03505
      Location:64 → 304
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:68 → 273
      FA_desaturase; Fatty acid desaturase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      48390713..48406198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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