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    Pum2 pumilio RNA-binding family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pum2provided by RGD
    Official Full Name
    pumilio RNA-binding family member 2provided by RGD
    Primary source
    RGD:1311024
    See related
    EnsemblRapid:ENSRNOG00000006180 AllianceGenome:RGD:1311024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Involved in several processes, including positive regulation of sprouting of injured axon; regulation of gene expression; and regulation of postsynapse assembly. Located in neuronal cell body. Is active in glutamatergic synapse and postsynapse. Orthologous to human PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 341.7), Spleen (RPKM 285.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pum2 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (37182130..37262223)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (31462879..31542976)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (33786184..33865693)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351200 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 Neighboring gene syndecan 1 Neighboring gene ribosomal protein S21, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function. Vessey JP, et al. Proc Natl Acad Sci U S A, 2010 Feb 16. PMID 20133610, Free PMC Article
    2. Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss. Yoon DS, et al. J Biomed Sci, 2023 Apr 23. PMID 37088847, Free PMC Article
    3. Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis. Cao Y, et al. Exp Cell Res, 2020 Aug 1. PMID 32437714
    4. MiR-495-3p promotes cardiac hypertrophy by targeting Pum2. Yu S, et al. Cell Mol Biol (Noisy-le-grand), 2024 Sep 8. PMID 39262254
    5. Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granules. Vessey JP, et al. J Neurosci, 2006 Jun 14. PMID 16775137, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-495-3p promotes cardiac hypertrophy by targeting Pum2.
      Title: MiR-495-3p promotes cardiac hypertrophy by targeting Pum2.
    2. Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss.
      Title: Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss.
    3. Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis.
      Title: Pum2 mediates Sirt1 mRNA decay and exacerbates hypoxia/reoxygenation-induced cardiomyocyte apoptosis.
    4. These results reveal that Pum2 shapes axonal transcriptomes by preventing the transport of Pumilio-binding elements -containing mRNAs into axons
      Title: Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body.
    5. Pumilio-2 is central to the homeostatic mechanism regulating membrane excitability in visual cortex pyramidal neurons.
      Title: Pumilio-2 regulates translation of Nav1.6 to mediate homeostasis of membrane excitability.
    6. Pumilio 2 regulates dendrite morphogenesis and synaptic function.
      Title: Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function.
    7. Mef2-induced expression of at least three individual miRNAs of the miR379-410 cluster is required for activity-dependent dendritic outgrowth of hippocampal neurons.
      Title: Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pumilio-response element binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of miRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sprouting of injured axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pumilio homolog 2
    Names
    pumilio 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106715.1 → NP_001100185.1  pumilio homolog 2 isoform 14

      See identical proteins and their annotated locations for NP_001100185.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A0A8I6AD36, A6HAM2, D3ZQL8
      Related
      ENSRNOP00000008359.5, ENSRNOT00000008359.8
      Conserved Domains (1) summary
      cd07920
      Location:718 → 1039
      Pumilio; Pumilio-family RNA binding domain

    2. NM_001434230.1 → NP_001421159.1  pumilio homolog 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K8F9, A0A8I6AD36

    3. NM_001434231.1 → NP_001421160.1  pumilio homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    4. NM_001434232.1 → NP_001421161.1  pumilio homolog 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    5. NM_001434233.1 → NP_001421162.1  pumilio homolog 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    6. NM_001434234.1 → NP_001421163.1  pumilio homolog 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    7. NM_001434235.1 → NP_001421164.1  pumilio homolog 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    8. NM_001434236.1 → NP_001421165.1  pumilio homolog 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    9. NM_001434237.1 → NP_001421166.1  pumilio homolog 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    10. NM_001434238.1 → NP_001421167.1  pumilio homolog 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZSK1, A0A8I6AD36

    11. NM_001434239.1 → NP_001421168.1  pumilio homolog 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    12. NM_001434240.1 → NP_001421169.1  pumilio homolog 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    13. NM_001434241.1 → NP_001421170.1  pumilio homolog 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    14. NM_001434242.1 → NP_001421171.1  pumilio homolog 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AD36

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      37182130..37262223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239879.5 → XP_006239941.1  pumilio homolog 2 isoform X1

      Conserved Domains (1) summary
      cd07920
      Location:722 → 1045
      Pumilio; Pumilio-family RNA binding domain

    2. XM_006239880.5 → XP_006239942.1  pumilio homolog 2 isoform X8

      Related
      ENSRNOP00000074592.3, ENSRNOT00000082598.3
      Conserved Domains (1) summary
      cd07920
      Location:722 → 1043
      Pumilio; Pumilio-family RNA binding domain

    3. XM_017594073.3 → XP_017449562.1  pumilio homolog 2 isoform X10

      Conserved Domains (1) summary
      cd07920
      Location:643 → 966
      Pumilio; Pumilio-family RNA binding domain

    4. XM_006239883.5 → XP_006239945.1  pumilio homolog 2 isoform X15

      Related
      ENSRNOP00000107432.1, ENSRNOT00000161902.1
      Conserved Domains (1) summary
      cd07920
      Location:643 → 964
      Pumilio; Pumilio-family RNA binding domain

    5. XM_039111924.2 → XP_038967852.1  pumilio homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AD36
      Conserved Domains (1) summary
      cd07920
      Location:721 → 1044
      Pumilio; Pumilio-family RNA binding domain

    6. XM_039111925.2 → XP_038967853.1  pumilio homolog 2 isoform X3

      Conserved Domains (1) summary
      cd07920
      Location:721 → 1042
      Pumilio; Pumilio-family RNA binding domain

    7. XM_039111936.2 → XP_038967864.1  pumilio homolog 2 isoform X11

      Conserved Domains (1) summary
      cd07920
      Location:642 → 965
      Pumilio; Pumilio-family RNA binding domain

    8. XM_039111938.2 → XP_038967866.1  pumilio homolog 2 isoform X12

      Conserved Domains (1) summary
      cd07920
      Location:642 → 963
      Pumilio; Pumilio-family RNA binding domain

    9. XM_039111928.2 → XP_038967856.1  pumilio homolog 2 isoform X4

    10. XM_063261634.1 → XP_063117704.1  pumilio homolog 2 isoform X6

    11. XM_039111939.2 → XP_038967867.1  pumilio homolog 2 isoform X13

      Conserved Domains (1) summary
      cd07920
      Location:638 → 959
      Pumilio; Pumilio-family RNA binding domain

    12. XM_039111930.2 → XP_038967858.1  pumilio homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AD36
      Conserved Domains (1) summary
      cd07920
      Location:716 → 1039
      Pumilio; Pumilio-family RNA binding domain

    13. XM_039111931.2 → XP_038967859.1  pumilio homolog 2 isoform X7

      Conserved Domains (1) summary
      cd07920
      Location:716 → 1037
      Pumilio; Pumilio-family RNA binding domain

    14. XM_063261638.1 → XP_063117708.1  pumilio homolog 2 isoform X14

    15. XM_063261642.1 → XP_063117712.1  pumilio homolog 2 isoform X16

    16. XM_063261636.1 → XP_063117706.1  pumilio homolog 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AD36
      Related
      ENSRNOP00000081323.2, ENSRNOT00000108134.2

    17. XM_063261637.1 → XP_063117707.1  pumilio homolog 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AD36

    18. XM_063261633.1 → XP_063117703.1  pumilio homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8F9, A0A8I6AD36

    19. XM_063261635.1 → XP_063117705.1  pumilio homolog 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AD36

    20. XM_063261639.1 → XP_063117709.1  pumilio homolog 2 isoform X10

    21. XM_063261641.1 → XP_063117711.1  pumilio homolog 2 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZSK1, A0A8I6AD36

    22. XM_063261640.1 → XP_063117710.1  pumilio homolog 2 isoform X11

    23. XM_063261643.1 → XP_063117713.1  pumilio homolog 2 isoform X17

    24. XM_063261644.1 → XP_063117714.1  pumilio homolog 2 isoform X18

    Nucleotide Protein Strain
    Heading Accession and Version

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