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    Rrh retinal pigment epithelium derived rhodopsin homolog [ Mus musculus (house mouse) ]

    Gene ID: 20132, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rrhprovided by MGI
    Official Full Name
    retinal pigment epithelium derived rhodopsin homologprovided by MGI
    Primary source
    MGI:MGI:1097709
    See related
    Ensembl:ENSMUSG00000028012 AllianceGenome:MGI:1097709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to be located in membrane. Predicted to be active in photoreceptor outer segment and plasma membrane. Is expressed in eye. Orthologous to human RRH (retinal pigment epithelium-derived rhodopsin homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 1.6), testis adult (RPKM 0.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rrh in Genome Data Viewer
    Location:
    3 G3; 3 59.09 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129596837..129618140, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129808575..129822505, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E827 Neighboring gene STARR-seq mESC enhancer starr_08971 Neighboring gene STARR-seq mESC enhancer starr_08975 Neighboring gene STARR-seq mESC enhancer starr_08976 Neighboring gene predicted gene, 35986 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:129256142-129256329 Neighboring gene ELOVL fatty acid elongase 6 Neighboring gene STARR-seq mESC enhancer starr_08981 Neighboring gene epidermal growth factor Neighboring gene STARR-positive B cell enhancer ABC_E6124 Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene predicted gene, 36130 Neighboring gene STARR-positive B cell enhancer ABC_E7942 Neighboring gene GAR1 ribonucleoprotein Neighboring gene predicted gene, 36180 Neighboring gene complement component factor i

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium. Cook JD, et al. J Biol Chem, 2017 Dec 29. PMID 29109151, Free PMC Article
    2. Expression of opsin genes early in ocular development of humans and mice. Tarttelin EE, et al. Exp Eye Res, 2003 Mar. PMID 12573668
    3. Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. Sun H, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275222, Free PMC Article
    4. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
    5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables photoreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    visual pigment-like receptor peropsin
    Names
    peropsin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409853.1 → NP_001396782.1  visual pigment-like receptor peropsin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC111097
      UniProtKB/TrEMBL
      Q80XL3
      Related
      ENSMUSP00000029648.8, ENSMUST00000029648.11

    2. NM_001409854.1 → NP_001396783.1  visual pigment-like receptor peropsin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC111097

    3. NM_001409855.1 → NP_001396784.1  visual pigment-like receptor peropsin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC111097

    4. NM_001409856.1 → NP_001396785.1  visual pigment-like receptor peropsin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC111097
      UniProtKB/TrEMBL
      A0A0G2JF76
      Related
      ENSMUSP00000143054.2, ENSMUST00000200079.5

    5. NM_009102.4 → NP_033128.1  visual pigment-like receptor peropsin isoform 2

      See identical proteins and their annotated locations for NP_033128.1

      Status: VALIDATED

      Source sequence(s)
      AC111097
      Consensus CDS
      CCDS38633.1
      UniProtKB/Swiss-Prot
      O35214
      UniProtKB/TrEMBL
      Q543W9
      Related
      ENSMUSP00000143093.2, ENSMUST00000196902.5
      Conserved Domains (1) summary
      pfam00001
      Location:43 → 294
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      129596837..129618140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319507.2 → XP_017174996.1  visual pigment-like receptor peropsin isoform X2

      UniProtKB/TrEMBL
      Q9D1T9
      Conserved Domains (2) summary
      cd14964
      Location:6 → 24
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1 → 170
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_036162965.1 → XP_036018858.1  visual pigment-like receptor peropsin isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:27 → 53
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:26 → 104
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35214.1 GenPept UniProtKB/Swiss-Prot:O35214

    Gene LinkOut

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